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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2015; 21(40): 11353-11361
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11353
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11353
Genetic epidemiology of irritable bowel syndrome
Jasbir Makker, Sridhar Chilimuri, Jonathan N Bella, Department of Medicine, Bronx-Lebanon Hospital Center and Albert Einstein College of Medicine, Bronx, NY 10457, United States
Author contributions: Makker J wrote the manuscript; Chilimuri S and Bella JN is the senior author who critically reviewed and revised the manuscript.
Conflict-of-interest statement: Authors have no conflict of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jonathan N Bella, MD, Department of Medicine, Bronx-Lebanon Hospital Center and Albert Einstein College of Medicine, 12th Floor, 1650 Grand Concourse, Bronx, NY 10457, United States. jonnbella@earthlink.net
Telephone: +1-718-5185222 Fax: +1-718-5185585
Received: April 20, 2015
Peer-review started: April 21, 2015
First decision: May 18, 2015
Revised: June 16, 2015
Accepted: August 25, 2015
Article in press: August 25, 2015
Published online: October 28, 2015
Processing time: 185 Days and 17.3 Hours
Peer-review started: April 21, 2015
First decision: May 18, 2015
Revised: June 16, 2015
Accepted: August 25, 2015
Article in press: August 25, 2015
Published online: October 28, 2015
Processing time: 185 Days and 17.3 Hours
Core Tip
Core tip: Irritable bowel syndrome (IBS) is believed to result from interplay of several factors including hypersensitivity of the bowel, altered bowel motility, inflammation and stress. Familial aggregation of cases and twin studies underscore the genetic basis of IBS. Different researchers have studied several candidate genes but the evidence so far linking IBS to specific genes is inconsistent and weak. Genome wide association studies that can examine several common genetic variants are needed to design newer drugs and diagnostic methods.