Suzuki H, Wada S, Araki K, Kubo N, Watanabe A, Tsukagoshi M, Kuwano H. Xanthogranulomatous cholecystitis: Difficulty in differentiating from gallbladder cancer. World J Gastroenterol 2015; 21(35): 10166-10173 [PMID: 26401081 DOI: 10.3748/wjg.v21.i35.10166]
Corresponding Author of This Article
Hideki Suzuki, MD, Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi 371-8511, Japan. hidesuzuki044@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hideki Suzuki, Satoshi Wada, Kenichiro Araki, Norio Kubo, Akira Watanabe, Mariko Tsukagoshi, Hiroyuki Kuwano, Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan
Author contributions: Suzuki H and Kuwano H designed the research; Suzuki H wrote the paper; Wada S, Araki K and Kubo N performed the research; Watanabe A and Tsukagoshi M analyzed the data.
Institutional review board statement: This study is not a formal study with a protocol; therefore, no submission was made the Hospital Ethics Review Board.
Informed consent statement: In this retrospective study, written informed consent was not provided by the participants, but the presented data are anonymized and risk of identification is low.
Conflict-of-interest statement: None of the authors of this manuscript have any conflicts of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at hidesuzuki044@gmail.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hideki Suzuki, MD, Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi 371-8511, Japan. hidesuzuki044@gmail.com
Telephone: +81-272-208224 Fax: +81-272-208230
Received: March 20, 2015 Peer-review started: March 25, 2015 First decision: April 23, 2015 Revised: May 13, 2015 Accepted: July 18, 2015 Article in press: July 18, 2015 Published online: September 21, 2015 Processing time: 181 Days and 18.9 Hours
Core Tip
Core tip: Xanthogranulomatous cholecystitis (XGC) is a rare inflammatory disease of the gallbladder. Differentiating between XGC and malignant gallbladder lesions is often difficult, especially in patients with severe proliferative fibrosis involving the gallbladder and surrounding organs. We compared the clinical features and computed tomography findings between patients with XGC and patients with advanced gallbladder cancer. There were almost no significant differences between the two groups. Although XGC is often difficult to differentiate from gallbladder carcinoma, it is possible to obtain an accurate diagnosis by careful intraoperative gross observation and several intraoperative frozen sections which could prevent extended resections.
