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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2015; 21(35): 10104-10112
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10104
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10104
Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis
Ying-Chun Wang, Lei Dong, Department of Gastroenterology, the Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Ying-Chun Wang, Wei-Zong Kong, Qing-Mei Jin, Juan Chen, Department of Gastroenterology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
Author contributions: Wang YC designed the research, analyzed the data and wrote the paper; Kong WZ performed the majority of research; Jin QM and Chen J performed the research; Dong L designed the research and provided fund support.
Institutional review board statement: The study was reviewed and approved by The Second Affiliated Hospital of Xi’an Jiaotong University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Dalian Medical University (IACUC protocol number: SCXK (Liao) 2013-0003).
Conflict-of-interest statement: The authors declare that there is no conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lei Dong, MD, Professor, Department of Gastroenterology, the Second Affiliated Hospital, Xi’an Jiaotong University, No. 157 Siwu Road, Beida Street, Xi’an 710004, Shaanxi Province, China. dong556@126.com
Telephone: +86-29-87679750 Fax: +86-29-876798758
Received: January 10, 2015
Peer-review started: January 10, 2015
First decision: March 13, 2015
Revised: April 25, 2015
Accepted: June 15, 2015
Article in press: June 15, 2015
Published online: September 21, 2015
Peer-review started: January 10, 2015
First decision: March 13, 2015
Revised: April 25, 2015
Accepted: June 15, 2015
Article in press: June 15, 2015
Published online: September 21, 2015
Core Tip
Core tip: This study applied salvianolic acid B (Sal B) as intervention for rats with nonalcoholic steatohepatitis (NASH). We also observed the changes in biochemical indexes, mitochondrial morphological characteristics and functions and apoptosis index before and after Sal B treatment was administered to explore the pathogenesis of NASH and therapeutic effects of Sal B. Sal B can treat NASH by protecting the morphological characteristics and functions of liver mitochondria, regulating lipid metabolism, controlling oxidative stress and lipid peroxidation and inhibiting apoptosis.