Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2015; 21(35): 10072-10079
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10072
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10072
Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation
Hanne Salmenkari, Tomi Issakainen, Heikki Vapaatalo, Riitta Korpela, Faculty of Medicine, Pharmacology, University of Helsinki, 00290 Helsinki, Finland
Author contributions: Salmenkari H, Vapaatalo H and Korpela R designed the research; Salmenkari H and Issakainen T performed the research; Salmenkari H analyzed the data; Salmenkari H, Vapaatalo H and Korpela R wrote the paper.
Supported by Grants from Foundation for Clinical Chemistry Research, Finland (partly).
Institutional review board statement: The study was reviewed and approved by the University of Helsinki, Pharmacology Institutional Review Board.
Institutional animal care and use committee statement: The study was approved by National Animal Experimentation Committee of Finland (ESAVI/6314/04.10.03/2012) according to EC Directive 86/609/ECC and Finnish Experimental Animal Act 62/2006.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at heikki.vapaatalo@helsinki.fi.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Heikki Vapaatalo, Professor Emeritus, Faculty of Medicine, Pharmacology, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland. heikki.vapaatalo@helsinki.fi
Telephone: +358-40-5257995 Fax: +358-40-5257995
Received: February 5, 2015
Peer-review started: February 7, 2015
First decision: April 13, 2015
Revised: April 30, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: September 21, 2015
Processing time: 224 Days and 14.7 Hours
Peer-review started: February 7, 2015
First decision: April 13, 2015
Revised: April 30, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: September 21, 2015
Processing time: 224 Days and 14.7 Hours
Core Tip
Core tip: Soluble and tissue levels of angiotensin-I converting enzyme (ACE) along with corticosterone production were examined in a dextran sulfate mouse model of intestinal inflammation. Intestine is a site of ACE shedding, which is increased by inflammation. ACE and corticosterone are increased in intestinal incubations of morphologically disrupted and intact parts of the intestine. ACE product Ang II stimulates corticosterone production in small intestine. The results suggest that intestinal Renin-Angiotensin system and glucocorticoids might be counter-regulatory systems in regulation of inflammatory processes in the intestine.