Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2015; 21(33): 9765-9773
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9765
Thyroid dysfunction in Chinese hepatitis C patients: Prevalence and correlation with TPOAb and CXCL10
Ren-Wen Zhang, Cui-Ping Shao, Na Huo, Min-Ran Li, Hong-Li Xi, Min Yu, Xiao-Yuan Xu
Ren-Wen Zhang, Cui-Ping Shao, Na Huo, Min-Ran Li, Hong-Li Xi, Min Yu, Xiao-Yuan Xu, Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
Author contributions: Xu XY designed the research; Zhang RW, Shao CP, Huo N, Li MR, Xi HL and Yu M performed the research; Zhang RW and Shao CP contributed new reagents/analytic tools; Zhang RW analyzed the data; Zhang RW and Xu XY wrote the paper.
Supported by National Major Project for Infectious Diseases Control, No. 2012ZX10002003-004-003; National Natural Science Foundation of China, No. 81373056; PhD Program Foundation of Ministry of Education of China, No. 20090001110081.
Institutional review board statement: The study was reviewed and approved by Peking University People Hospital Institutional Review Board.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiao-Yuan Xu, Professor, Department of Infectious Diseases, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. xiaoyuanxu6@163.com
Telephone: +86-10-83575787
Received: April 9, 2015
Peer-review started: April 9, 2015
First decision: May 18, 2015
Revised: June 2, 2015
Accepted: July 8, 2015
Article in press: July 8, 2015
Published online: September 7, 2015
Processing time: 151 Days and 5.8 Hours
Core Tip

Core tip: We present novel data on the influence of peginterferon alfa-2a/ribavirin (PegIFNα-2a/RBV) on thyroid function in Chinese genotype 1 hepatitis C virus (HCV)-infected patients over a 48-wk treatment period. The results demonstrate that the prevalence of thyroid dysfunction (TD) was 18.0%. Lower pretreatment serum CXCL10 levels were associated with PegIFNα-2a/RBV induced TD in genotype 1 HCV-infected patients, and female patients exhibited an increased risk for developing TD compared with male patients. Baseline TPOAb positivity may also be a risk factor for TD development. However, most (84%) of the TD cases were reversible. To our knowledge, this is the first study to investigate the association of CXCL10 levels with PegIFNα-2a/RBV induced TD in genotype 1 HCV-infected patients in China.