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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2015; 21(33): 9727-9735
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9727
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9727
Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells
Bing Han, Jian-Ping Wang, Yu-Kun Cao, Jun Liu, Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China
Shi-Hai Liu, Central Laboratory, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Bing Han, Wei-Dong Guo, Bin Zhang, Department of Hepatobilliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Han B and Liu SH contributed equally to this work; Han B, Liu SH, Guo WD, Zhang B, Wang JP, Cao YK and Liu J designed the research; Han B, Liu SH, Wang JP and Cao YK performed the research; Han B, Liu SH, Guo WD and Zhang B analyzed the data; Han B and Liu SH wrote the paper; all authors read and approved the final manuscript.
Supported by Shandong Provincial Natural Science Foundation, China, No. ZR2012HQ039 and No. ZR2014HP065; National Natural Science Foundation of China, No. 81373172 and No.81402579.
Conflict-of-interest statement: There is no conflict of interest in this study.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jun Liu, MD, PhD, Professor, Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. dr_junliu@163.com
Telephone: +86-531-68776905 Fax: +86-531-68776905
Received: March 15, 2015
Peer-review started: March 15, 2015
First decision: April 13, 2015
Revised: June 6, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: September 7, 2015
Processing time: 176 Days and 6.1 Hours
Peer-review started: March 15, 2015
First decision: April 13, 2015
Revised: June 6, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: September 7, 2015
Processing time: 176 Days and 6.1 Hours
Core Tip
Core tip: The down-regulation of Notch1 by γ-secretase inhibitor (GSI-I) or siRNA combined with interleukin (IL)-24, could sensitize apoptosis, increase expression of E-cadherin and decrease the invasion and migration capabilities of HepG2 cells. These results indicate for the first time that GSI-I/IL-24 combination might represent a novel and potentially effective tool for hepatocellular carcinoma treatment.