Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2015; 21(33): 9717-9726
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9717
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9717
Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer
Yu Yan, Li-Feng Wang, Rui-Fen Wang, Department of Pathology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Author contributions: Wang LF designed this review; Yan Y and Wang RF wrote the manuscript; Yan Y and Wang RF edited the manuscript.
Conflict-of-interest statement: We declare that there are no conflicts of interest related to this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Li-Feng Wang, MD, PhD, Professor, Department of Pathology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. wlf6009@163.com
Telephone: +86-21-25077215 Fax: +86-21-25077215
Received: April 24, 2015
Peer-review started: April 26, 2015
First decision: May 18, 2015
Revised: June 5, 2015
Accepted: July 18, 2015
Article in press: July 18, 2015
Published online: September 7, 2015
Processing time: 135 Days and 17.3 Hours
Peer-review started: April 26, 2015
First decision: May 18, 2015
Revised: June 5, 2015
Accepted: July 18, 2015
Article in press: July 18, 2015
Published online: September 7, 2015
Processing time: 135 Days and 17.3 Hours
Core Tip
Core tip: Gastric cancer (GC) is one of the most common cancers worldwide. GC usually metastasizes to distant organs in advanced stages. Cancer-associated fibroblasts (CAFs) play an important role in GC invasion and metastasis. Therefore, a better understanding of the special interaction between GC cells and CAFs may be useful for identifying the underlying mechanisms of tumor progression.