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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2015; 21(32): 9607-9613
Published online Aug 28, 2015. doi: 10.3748/wjg.v21.i32.9607
Published online Aug 28, 2015. doi: 10.3748/wjg.v21.i32.9607
Comparison of effects of obesity and non-alcoholic fatty liver disease on incidence of type 2 diabetes mellitus
Wei-Dong Li, Jin-Rong Xia, Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Kun-Fa Fu, Jiangsu Provincial Geriatric Hospital, Nanjing 210010, Jiangsu Province, China
Gui-Mei Li, Department of Pathology, 81st Hospital of the People’s Liberation Army, Nanjing, 210002, Jiangsu Province, China
Yan-Shu Lian, Department of Preventive Medicine, Jiankang Vocational College, Nanjing 210036, Jiangsu Province, China
Ai-Min Ren, Physical Examination Center, Nanjing Branch, Jiangsu Armed Police General Hospital, Nanjing 210028, Jiangsu Province, China
Yun-Jue Chen, Occupational Health Management Center, Nanjing Hospital of Occupational Disease Control, Nanjing 210042, Jiangsu Province, China
Author contributions: Li WD, Fu KF, Ren AM, Chen YJ, Li GM and Xia JR contributed to the experimental design, data collection, and data collation; Li WD wrote and revised the manuscript; Lian YS analyzed the data; all authors read and approved the final version to be published.
Conflict-of-interest statement: The authors disclose no conflicts of interest in this study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at xjr049540@163.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jin-Rong Xia, Chief Physician, Associate Professor, Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Dingjia Qiao Road, Nanjing Gulou District, Nanjing 210009, Jiangsu Province, China. xjr049540@163.com
Telephone: +86-25-83262831 Fax: +86-25-83272356
Received: January 12, 2015
Peer-review started: January 13, 2015
First decision: April 24, 2015
Revised: May 25, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: August 28, 2015
Peer-review started: January 13, 2015
First decision: April 24, 2015
Revised: May 25, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: August 28, 2015
Core Tip
Core tip: A population of 4847 Chinese subjects was randomly sampled from 17 medical units for enrollment in this cohort study with a 4-year follow-up. The effects of obesity and non-alcoholic fatty liver disease (NAFLD) were compared and analyzed on the incidence of type 2 diabetes mellitus (T2DM). Compared with body mass index, NAFLD could be better at forecasting the risk of T2DM in Chinese subjects, and may be a high risk factor for T2DM, independent of overweight/obesity.