Chang YT, Chang MC, Tung CC, Wei SC, Wong JM. Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis. World J Gastroenterol 2015; 21(32): 9534-9543 [PMID: PMC4548114 DOI: 10.3748/wjg.v21.i32.9534]
Corresponding Author of This Article
Yu-Ting Chang, MD, MS, PhD, Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung Shan South Road, Taipei, Taiwan. yutingchang@ntu.edu.tw
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 28, 2015; 21(32): 9534-9543 Published online Aug 28, 2015. doi: 10.3748/wjg.v21.i32.9534
Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis
Yu-Ting Chang, Ming-Chu Chang, Chien-Chih Tung, Shu-Chen Wei, Jau-Min Wong
Yu-Ting Chang, Ming-Chu Chang, Shu-Chen Wei, Jau-Min Wong, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 101, Taiwan
Chien-Chih Tung, Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 101, Taiwan
Author contributions: Chang YT and Chang MC contributed to the study concept and design and conducted the experiments; Chang YT, Chang MC, Tung CC, Wei SC and Wong JM analyzed and interpreted the data; Chang YT drafted the manuscript; and Chang YT and Wong JM supervised the study.
Institutional animal care and use committee statement: The animal use for this study was reviewed and approved by the National Taiwan University College of Medicine and College of Public Health Institutional Animal Care and Use Committee, No. 20080297.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu-Ting Chang, MD, MS, PhD, Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung Shan South Road, Taipei, Taiwan. yutingchang@ntu.edu.tw
Received: March 14, 2015 Peer-review started: March 16, 2015 First decision: May 18, 2015 Revised: June 1, 2015 Accepted: July 8, 2015 Article in press: July 8, 2015 Published online: August 28, 2015 Processing time: 167 Days and 0 Hours
Core Tip
Core tip: The mechanism by which severe hypertriglyceridemia precipitates acute pancreatitis remains unknown. Abnormal sustained elevated cytosolic Ca2+ signals, which cause abnormal intracellular enzyme activation, are crucial in the initiation of acute pancreatitis. Unsaturated fatty acids at high concentrations induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells and caused intra-acinar cell trypsin activation and cell damage. Unsaturated fatty acids at low concentrations and saturated fatty acids and triglycerides at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations may play a crucial and distinctive role in the pathogenesis of hypertriglyceridemic pancreatitis.
