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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2015; 21(31): 9348-9357
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9348
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9348
Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma
Dou-Dou Li, Yi-Min Liu, Department of Radiotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Zhi-Qiang Fu, Qing Lin, Yu Zhou, Quan-Bo Zhou, Lang-Ping Tan, Ru-Fu Chen, Department of Pancreaticobiliary and Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Zhi-Hua Li, Department of Medical Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Author contributions: Li DD and Fu ZQ contributed equally to this study; Li DD and Fu ZQ performed the majority of experiments; Lin Q conducted part of the experiments, and contributed to the revision of this paper; Zhou Y and Zhou QB conceived the experiments, analyzed and interpreted the data, and wrote the manuscript; Li ZH and Tan LP participated in the experiments and helped to analyze the data; all authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Sun Yat-sen Memorial Hospital.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors disclose no conflicts.
Data sharing statement: The technical appendix, statistical code, and dataset are available from the corresponding author at liuyimin_sysu@163.com. Consent was not obtained but the presented data are anonymized and the risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yi-Min Liu, Department of Radiotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan-Jiang Xi Road, Guangzhou 510120, Guangdong Province, China. liuyimin_sysu@163.com
Telephone: +86-20-81332480 Fax: +86-20-81332480
Received: January 28, 2015
Peer-review started: January 29, 2015
First decision: March 10, 2015
Revised: April 7, 2015
Accepted: June 16, 2015
Article in press: June 16, 2015
Published online: August 21, 2015
Peer-review started: January 29, 2015
First decision: March 10, 2015
Revised: April 7, 2015
Accepted: June 16, 2015
Article in press: June 16, 2015
Published online: August 21, 2015
Core Tip
Core tip: This is the first study to report that linc00675 is more highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues than in adjacent normal tissues. Overexpression of linc00675 in PDAC tissues positively correlated with short survival and tumor progression. The prominent finding in this study is that linc00675 is an independent prognostic marker for predicting the survival of PDAC patients after surgery.