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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2015; 21(31): 9317-9327
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9317
Published online Aug 21, 2015. doi: 10.3748/wjg.v21.i31.9317
Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases
Sahar Honarmand-Jahromy, Taher Nejad Sattari, Department of Biology, Tehran Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran
Farideh Siavoshi, Department of Microbiology, School of Biology, University College of Sciences, University of Tehran, Tehran 1417614411, Iran
Reza Malekzadeh, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran 1411713135, Iran
Saeid Latifi-Navid, Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil 5619911367, Iran
Author contributions: Siavoshi F and Latifi-Navid S designed the study; Honarmand-Jahromy S performed the research; Malekzadeh R provided the gastric biopsy specimens; Nejad Sattari T analyzed the data; and Siavoshi F wrote the paper.
Supported by Research Council of the University of Tehran.
Institutional review board statement: The study was approved by the research Ethics Committee of Tehran University of Medical Sciences. All patients signed written informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Parts of the study have been presented at the XXVIIth International Workshop on Helicobacter and Microbiota in Chronic Digestive Inflammation and Gastric Cancer.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Farideh Siavoshi, PhD, Department of Microbiology, School of Biology, University College of Sciences, University of Tehran, Enghelab Avenue, Tehran 1417614411, Iran. siavoshi@khayam.ut.ac.ir
Telephone: +98-21-61112460 Fax: +98-21-66492992
Received: January 3, 2015
Peer-review started: January 4, 2015
First decision: February 10, 2015
Revised: March 22, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: August 21, 2015
Processing time: 228 Days and 18.2 Hours
Peer-review started: January 4, 2015
First decision: February 10, 2015
Revised: March 22, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: August 21, 2015
Processing time: 228 Days and 18.2 Hours
Core Tip
Core tip:Helicobacter pylori (H. pylori) genotype and host and environmental factors have emerged as the risk factors of H. pylori-associated diseases. However, controversies exist regarding the reciprocal interaction between these factors. Results of this study demonstrate that increased age is an important risk factor for gastric ulcers in both males and females, for chronic gastritis in females, and for duodenal ulcers in males. Genotypes vacA s1 and vacA s2m2 emerged as significant risk factors for duodenal ulcers, and chronic gastritis and gastric ulcers, respectively. No correlation was found between vacA m or cagA and gastric diseases.