Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2015; 21(30): 9217-9222
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9217
Esophageal stenosis with sloughing esophagitis: A curious manifestation of graft-vs-host disease
Daniel Trabulo, Sara Ferreira, Pedro Lage, Rafaela Lima Rego, Gilda Teixeira, A Dias Pereira
Daniel Trabulo, Gastroenterology Department, Hospital de São Bernardo, Centro Hospitalar de Setúbal E.P.E., 2910-446 Setúbal, Portugal
Sara Ferreira, Pedro Lage, A Dias Pereira, Gastroenterology Department, Instituto Português de Oncologia de Lisboa de Francisco Gentil, 1099-023 Lisboa, Portugal
Rafaela Lima Rego, Pathology Department, Instituto Português de Oncologia de Lisboa de Francisco Gentil, 1099-023 Lisboa, Portugal
Gilda Teixeira, Hemathology Department, Instituto Português de Oncologia de Lisboa de Francisco Gentil, 1099-023 Lisboa, Portugal
Author contributions: Trabulo D was involved in the endoscopic management of the patient, made the review of the literature and wrote the manuscript; Ferreira S, Lage P and Pereira AD were involved in the endoscopic management of the patient and revised the manuscript; Rego RL examined the biopsies and made the pathological diagnosis; and Teixeira G was the medical assistent of the patient and was involved in her treatment
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Centro Hospitalar de Setúbal E.P.E. and Instituto Português de Oncologia de Lisboa de Francisco Gentil.
Informed consent statement: The patient provided informed written consent.
Conflict-of-interest statement: The authors declare no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Daniel Trabulo, Gastroenterology Department, Hospital de São Bernardo, Centro Hospitalar de Setúbal E.P.E., Rua Camilo Castelo Branco, 2910-446 Setúbal, Portugal. danieltrabulo@yahoo.com
Telephone: +351-265-549000 Fax: +351-265-238066
Received: February 27, 2015
Peer-review started: February 27, 2015
First decision: April 13, 2015
Revised: April 26, 2015
Accepted: June 9, 2015
Article in press: June 10, 2015
Published online: August 14, 2015
Processing time: 171 Days and 4.1 Hours
Core Tip

Core tip: Esophageal manifestations of graft-vs-host disease (GVHD) are very rare. We report a case of sloughing esophagitis along with severe stenosis requiring endoscopic dilation, as a manifestation of chronic GVHD, after allogenic bone marrow transplantation. This manifestation has never been reported in this context. Endoscopy may play a significant role in early diagnosis and treatment of esophageal GVHD. Histological examination of gastrointestinal biopsies is needed to confirm the diagnosis.