Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2015; 21(30): 9093-9102
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9093
Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells
Yan-Ling Chen, Jun-Jiao Song, Xiao-Chun Chen, Wei Xu, Qiang Zhi, Yun-Peng Liu, Hong-Zhi Xu, Jin-Shui Pan, Jian-Lin Ren, Bayasi Guleng
Yan-Ling Chen, Jun-Jiao Song, Xiao-Chun Chen, Wei Xu, Qiang Zhi, Yun-Peng Liu, Hong-Zhi Xu, Jin-Shui Pan, Jian-Lin Ren, Bayasi Guleng, Department of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University, Xiamen 361004, Fujian Province, China
Author contributions: Chen YL and Song JJ contributed equally to this work; Chen YL, Song JJ, Ren JL and Guleng B designed the study; Chen YL, Song JJ, Chen XC, Xu W, Zhi Q and Liu YP carried out the study; Xu HZ and Pan JS contributed new reagents and annalytic tools; Chen YL, Song JJ and Liu YP analyzed the data; Liu YP and Guleng B wrote the paper.
Supported by National Natural Science Foundation of China, No. 81370505, No. 81370591, No. 81225025, No. 81100285 and No. 91229201; grants from Ministry of Health Foundation for State Key Clinical Department, 863 and 973 programs in China, No. 2012AA02A201 and No. 2013CB944903.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Bayasi Guleng, Department of Gastroenterology, Zhongshan Hospital affiliated with Xiamen University, No. 201 Hubin South Road, Xiamen 361004, Fujian Province, China. bayasi8@gmail.com
Telephone: +86-592-2292371 Fax: +86-592-2212328
Received: September 26, 2014
Peer-review started: September 27, 2014
First decision: December 2, 2014
Revised: January 8, 2015
Accepted: June 9, 2015
Article in press: June 10, 2015
Published online: August 14, 2015
Processing time: 324 Days and 19 Hours
Core Tip

Core tip: The present study is to explore the effects of pyruvate kinase M2 (PKM2) on motility of human hepatocellular carcinoma cells. Here, our results revealed that silenced PKM2 activated the epidermal growth factor (EGF)/EGFR and transforming growth factor beta (TGFβ)/TGFR signaling pathways, in addition, up-regulate the expression of downstream targets, and this is the first research to connect PKM2 with the vital EGF and TGFβ pathways in hepatocellular carcinoma cell motility.