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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2015; 21(30): 9021-9037
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9021
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9021
Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis
Juliana Carvalho Santos, Marcelo Lima Ribeiro, Sao Francisco University Medical School Clinical Pharmacology and Gastroenterology Unit Laboratory of Microbiology and Molecular Biology, Bragança Paulista, SP 12916900, Brazil
Juliana Carvalho Santos, Marcelo Lima Ribeiro, UNICAMP, Universidade Estadual de Campinas, Genetics and Molecular Biology, Campinas, SP 12916900, Brazil
Author contributions: Santos JC and Ribeiro ML solely contributed to this paper.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marcelo L Ribeiro, Bsc, PhD, Sao Francisco University Medical School Clinical Pharmacology and Gastroenterology Unit Laboratory of Microbiology and Molecular Biology, Bragança Paulista, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulist, SP 12916900, Brazil. marcelo.ribeiro@usf.edu.br
Telephone: +55-11-24548982 Fax: +55-11-40341825
Received: April 28, 2015
Peer-review started: April 28, 2015
First decision: May 18, 2015
Revised: June 2, 2015
Accepted: July 8, 2015
Article in press: July 8, 2015
Published online: August 14, 2015
Processing time: 111 Days and 9.4 Hours
Peer-review started: April 28, 2015
First decision: May 18, 2015
Revised: June 2, 2015
Accepted: July 8, 2015
Article in press: July 8, 2015
Published online: August 14, 2015
Processing time: 111 Days and 9.4 Hours
Core Tip
Core tip: Considering the relevance of DNA repair mechanisms in the maintenance of genome integrity and the role of epigenetics in its regulation on gastric carcinogenesis, in this review, we highlight the effects of Helicobacter pylori infection on the modulation of epigenetics mechanisms regulating DNA repair pathways associated with gastric carcinogenesis.