Wu ZF, Wu XY, Zhu N, Xu Z, Li WS, Zhang HB, Yang N, Yao XQ, Liu FK, Yang GS. Prognosis after resection for hepatitis B virus-associated intrahepatic cholangiocarcinoma. World J Gastroenterol 2015; 21(3): 935-943 [PMID: 25624728 DOI: 10.3748/wjg.v21.i3.935]
Corresponding Author of This Article
Xue-Quan Yao, MD, Department of Surgical Oncology, Jiangsu Province Hospital of Traditional Chinese Medicine, the Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. xuequan000@126.com
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 21, 2015; 21(3): 935-943 Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.935
Prognosis after resection for hepatitis B virus-associated intrahepatic cholangiocarcinoma
Zhen-Feng Wu, Xiao-Yu Wu, Nan Zhu, Zhe Xu, Wei-Su Li, Hai-Bin Zhang, Ning Yang, Xue-Quan Yao, Fu-Kun Liu, Guang-Shun Yang
Zhen-Feng Wu, Xiao-Yu Wu, Zhe Xu, Wei-Su Li, Xue-Quan Yao, Fu-Kun Liu, Department of Surgical Oncology, Jiangsu Province Hospital of Traditional Chinese Medicine, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Nan Zhu, Hai-Bin Zhang, Ning Yang, Guang-Shun Yang, Fifth Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Author contributions: Yao XQ, Wu ZF, Wu XY and Zhu N conceived and designed the study; Wu ZF and Li WS acquired the data; Xu Z, Yang N and Liu FK controlled the quality of data and algorithms; Zhang HB, Wu ZF and Yang GS analysed and interpreted the data; Wu ZF and Liu FK performed statistical analysis; Wu ZF, Wu XY and Zhu N contributed equally to this work.
Supported by National Natural Science Foundation of China, No. 81402523.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xue-Quan Yao, MD, Department of Surgical Oncology, Jiangsu Province Hospital of Traditional Chinese Medicine, the Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. xuequan000@126.com
Telephone: +86-25-86617141 Fax: +86-25-86617141
Received: May 14, 2014 Peer-review started: May 14, 2014 First decision: June 18, 2014 Revised: July 12, 2014 Accepted: September 18, 2014 Article in press: September 19, 2014 Published online: January 21, 2015 Processing time: 251 Days and 9.5 Hours
Core Tip
Core tip: Some recently published studies show a relation between chronic hepatitis B infection and the development of intrahepatic cholangiocarcinoma. Hepatitis B-associated patients with cholangiocarcinoma appear to have different clinicopathological characteristics compared with seronegative patients. In this context, the authors analyzed the data of patients with hepatitis B virus-associated intrahepatic cholangiocarcinoma who underwent curative resection retrospectively. They found in multivariate analysis that liver cirrhosis and multiple tumors were independent prognostic factors for overall survival. Independent prognostic factors for disease-free survival were liver cirrhosis, vascular invasion and advanced TNM stage. The patients were divided into three groups depending on the extent of lymph node dissection (no lymph node dissection, sampling lymph node dissection and regional lymph node dissection). The outcomes were not statistically different between the three groups.
