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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2015; 21(29): 8894-8902
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8894
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8894
Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis
Takayuki Kondo, Hitoshi Maruyama, Tadashi Sekimoto, Taro Shimada, Masanori Takahashi, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Author contributions: Maruyama H was responsible for the study concept and design; Kondo T, Maruyama H, Sekimoto T, Shimada T and Takahashi M collected the data; Kondo T and Maruyama H analyzed the data; Kondo T drafted the manuscript; and Maruyama H and Yokosuka O provided critical revisions of the manuscript for important intellectual content.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki, and was approved by the Ethics Committee of Chiba University Graduate School of Medicine.
Informed consent statement: Informed written consent for research use of medical records was obtained from all of the patients.
Conflict-of-interest statement: All of the authors declare that there are no potential conflicts of interest and that they have received no funding for this paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hitoshi Maruyama, MD, PhD, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuou-ku, Chiba 260-8670, Japan. maru-cib@umin.ac.jp
Telephone: +81-43-2262083 Fax: +81-43-2262088
Received: January 16, 2015
Peer-review started: January 17, 2015
First decision: April 13, 2015
Revised: April 27, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: August 7, 2015
Processing time: 203 Days and 21 Hours
Peer-review started: January 17, 2015
First decision: April 13, 2015
Revised: April 27, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: August 7, 2015
Processing time: 203 Days and 21 Hours
Core Tip
Core tip: The influence of non-forward portal flow (NFPF) in cirrhosis has not been determined. The present study examined the effect of NFPF on the natural history of cirrhosis in 222 patients (median follow-up period 40.9 mo). The cumulative incidences of NFPF was as follows: 6.5% at 1 year, 14.5% at 3 years, and 23.1% at 5 years. The cumulative survival rate was significantly lower in patients with NFPF (72.2% at 1 year, 38.5% at 3 years, and 38.5% at 5 years) than in those with forward portal flow (84.0% at 1 year, 67.8% at 3 years, and 54.3% at 5 years, P = 0.0123) using Child-Pugh B and C classifications, suggesting the need for careful management of these patients.