Randomized Controlled Trial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2015; 21(26): 8184-8194
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.8184
Intraprocedural bowel cleansing with the JetPrep cleansing system improves adenoma detection
Arthur Hoffman, Sanjay Murthy, Lena Pompetzki, Johannes Wilhelm Rey, Martin Goetz, Achim Tresch, Peter Robert Galle, Ralf Kiesslich
Arthur Hoffman, Johannes Wilhelm Rey, Martin Goetz, Peter Robert Galle, Ralf Kiesslich, First Department of Medicine, Johannes Gutenberg University of Mainz, 65199 Wiesbaden, Germany
Arthur Hoffman, Johannes Wilhelm Rey, Department of Internal Medicine II, HSK Hospital, Teaching Hospital of the University Medicine of Mainz, 55131 Mainz, Germany
Sanjay Murthy, The Ottawa Hospital and University of Ottawa, Ottawa, ON K1H 8L6, Canada
Lena Pompetzki, Department of Urology, Health and Care Center Ruesselsheim, 65428 Ruesselsheim, Germany
Martin Goetz, First Department of Medicine, University of Tuebingen, 72076 Tuebingen, Germany
Achim Tresch, Max Planck Institute, 50931 Cologne, Germany
Author contributions: Hoffman A designed and performed the research, wrote the manuscript, and contributed to data analysis, interpretation, and provision of study material and patients; Murthy S performed the research and collected and/or assembled the data; Pompetzki L analyzed, collected and/or assembled the data; Tresch A and Rey JW analyzed and interpreted the data; Goetz M analyzed the data; Galle PR and Kiesslich R performed the research and gave administrative support.
Institutional review board statement: The study was reviewed and approved by the Ethical Review Committee of the University of Mainz.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at ahoff66286@aol.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Arthur Hoffman, MD, PhD, Department of Internal Medicine II, HSK Hospital, Teaching Hospital of the University Medicine of Mainz, 65199 Wiesbaden, Germany. ahoff66286@aol.com
Telephone: +49-611-432420 Fax: +49-611-432418
Received: December 1, 2014
Peer-review started: December 1, 2014
First decision: February 10, 2015
Revised: March 18, 2015
Accepted: April 3, 2015
Article in press: April 3, 2015
Published online: July 14, 2015
Core Tip

Core tip: Stool tends to hinder visibility during colonoscopy, and its presence therefore increases the risk that lesions will be overlooked. The JetPrep system is an irrigation system that was designed for intraprocedural colon cleansing. The aim of this randomized, prospective study was to investigate the impact of JetPrep cleansing on detection rates of adenomas. The JetPrep system enabled better cleansing of the colon, which increased the detection of polyps throughout the entire colon and especially on its right side (P < 0.001). Based on the results of this study, the JetPrep flushing device may be broadly recommended for use during screening colonoscopy to improve bowel preparation and to increase polyp detection rates.