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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2015; 21(26): 8052-8060
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.8052
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.8052
Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects
Xiao-Dong Wang, Ning-Ning Gao, Yu-Wen Diao, Yu Liu, Dong Gao, Wang Li, Yan-Yan Wan, Jing-Jing Zhong, Guang-Yi Jin, School of Medicine, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Xiao-Dong Wang, Ning-Ning Gao, Yu-Wen Diao, Yu Liu, Dong Gao, Wang Li, Yan-Yan Wan, Jing-Jing Zhong, Guang-Yi Jin, Shenzhen Engineering Laboratory of Synthetic Biology, Shenzhen 518060, Guangdong Province, China
Yu-Wen Diao, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Medicine, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Yu Liu, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Author contributions: Wang XD, Gao NN, Diao YW, Liu Y and Jin GY designed the research; Wang XD, Gao NN, Gao D, Li W, Wan YY and Zhong JJ performed the research; Wang XD, Gao NN, Diao YW and Liu Y analyzed the data; and Wang XD wrote the paper.
Supported by National Natural Science Foundation of China, No. 81202396 and No. 81273374; and grants from the Science Foundation of Shenzhen, No. JCYJ20130326112757843.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Shenzhen University, China.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at gyjin@szu.edu.cn. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guang-Yi Jin, PhD, Professor of Medicinal Chemistry, School of Medicine, Shenzhen University, No. 3688 Nanhai Avenue, Shenzhen 518060, Guangdong Province, China. gyjin@szu.edu.cn
Telephone: +86-755-86670303 Fax: +86-755-86671906
Received: December 26, 2014
Peer-review started: December 27, 2014
First decision: January 22, 2015
Revised: April 1, 2015
Accepted: May 20, 2015
Article in press: May 21, 2015
Published online: July 14, 2015
Peer-review started: December 27, 2014
First decision: January 22, 2015
Revised: April 1, 2015
Accepted: May 20, 2015
Article in press: May 21, 2015
Published online: July 14, 2015
Core Tip
Core tip: Immunization with toll-like receptor-7 agonist conjugated with a monoclonal gastric cancer 7 antigen tri-epitope was efficacious in reversing tolerance and generating a therapeutic response in Ehrlich ascites carcinoma tumor-bearing mice. This occurred by enhancing the specific humoral and cellular immunity, which were displayed as higher antibody titers, antibody-dependent cell-mediated cytotoxicity, and cytotoxic T lymphocyte activity.