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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2015; 21(25): 7742-7753
Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7742
Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7742
Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats
Dongmei Jia, Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu 807-8555, Japan
Dongmei Jia, Molecular Cytogenetics Laboratory, SSM Cardinal Glennon Children’s Medical Center, St Louis, MO 63104, United States
Mitsuyoshi Yamamoto, Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu 807-8555, Japan
Makoto Otsuki, Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu 807-8555, Japan
Makoto Otsuki, Kita-Suma Hospital, Suma-ku, Kobe 654-0102, Japan
Author contributions: Jia D performed the research, analyzed the data and wrote the paper; Yamamoto M analyzed the data; Otsuki M designed the research, analyzed the data and wrote the paper; all authors contributed to the manuscript.
Supported by Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan, No. 10470144; and the Japanese Ministry of Health, Labour and Welfare (Intractable Diseases of the Pancreas).
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at mac.otsk@gmail.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Makoto Otsuki, MD, PhD, Kita-Suma Hospital, 1-1-1 Higashi-Shirakawadai, Suma-ku, Kobe 654-0102, Japan. mac.otsk@gmail.com
Telephone: +81-78-743-6666 Fax: +81-78-743-1230
Received: December 29, 2014
Peer-review started: December 30, 2014
First decision: January 22, 2015
Revised: February 13, 2015
Accepted: March 27, 2015
Article in press: March 27, 2015
Published online: July 7, 2015
Processing time: 190 Days and 18 Hours
Peer-review started: December 30, 2014
First decision: January 22, 2015
Revised: February 13, 2015
Accepted: March 27, 2015
Article in press: March 27, 2015
Published online: July 7, 2015
Processing time: 190 Days and 18 Hours
Core Tip
Core tip: In experimental acute hemorrhagic pancreatitis, feeding ad libitum without any treatment delayed biochemical, histological and functional recovery. Both pancreatic rest made by blocking cholecystokinin (CCK)-1 receptor and pancreatic stimulation caused by eliciting endogenous CCK release improved biochemical and histological alterations, except pancreatic secretory function. The favorable treatment strategy for acute pancreatitis (AP) is to keep the pancreas at rest during an early stage followed by pancreatic stimulation. Thus, high-protein meals should be avoided during the early phase after AP but protein meals may be important at later times to stimulate recovery of pancreatic function.