Review
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World J Gastroenterol. Jul 7, 2015; 21(25): 7672-7682
Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7672
Gene polymorphisms associated with functional dyspepsia
Anastasia Kourikou, George P Karamanolis, George D Dimitriadis, Konstantinos Triantafyllou
Anastasia Kourikou, George D Dimitriadis, Konstantinos Triantafyllou, Hepatogastroenterology Unit, Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Medical School, Athens University, 12462 Haidari, Greece
George P Karamanolis, Academic Department of Gastroenterology, Laiko General Hospital, Medical School, Athens University, 11527 Athens, Greece
Author contributions: Kourikou A searched the literature, drafted and finally approved the manuscript; Karamanolis GP and Dimitriadis GD reviewed the draft and finally approved the manuscript; Triantafyllou K conceived the idea, reviewed the draft and finally approved the manuscript.
Conflict-of-interest statement: Authors have nothing to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Konstantinos Triantafyllou, Assistant Professor, Hepatogastroenterology Unit, Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Medical School, Athens University, Rimini 1, 12462 Haidari, Greece. ktriant@med.uoa.gr
Telephone: +30-210-5832087 Fax: +30-210-5326422
Received: February 23, 2015
Peer-review started: February 25, 2015
First decision: March 26, 2015
Revised: April 7, 2015
Accepted: May 21, 2015
Article in press: May 21, 2015
Published online: July 7, 2015
Processing time: 134 Days and 18.7 Hours
Core Tip

Core tip: Functional dyspepsia is a common disorder with complex pathophysiology. Recent evidence has shown that certain gene polymorphisms might be implicated in its pathogenesis; however, results are inconsistent. Further studies are required to develop new data that provide novel insights regarding the mechanisms of genetic susceptibility in functional dyspepsia.