Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2015; 21(24): 7443-7456
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7443
Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance
Tawfik Khoury, Ami Ben Ya'acov, Yehudit Shabat, Lidya Zolotarovya, Ram Snir, Yaron Ilan
Tawfik Khoury, Ami Ben Ya'acov, Yehudit Shabat, Lidya Zolotarovya, Ram Snir, Yaron Ilan, Gastroeneterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem IL-91120, Israel
Author contributions: Khoury T and Ben Ya'acov A contributed equally to this work; Khoury T, Ben Ya'acov A, Shabat Y and Zolotarovya L conducted the experiments and summarized the data; Khoury T, Ben Ya'acov A, Snir R and Ilan Y prepared the manuscript.
Supported by Grants from The Roaman-Epstein Liver Research Foundation (partly, to Ilan Y).
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use committee of the Hebrew University Hadassah Medical Center (IACUC protocol number: MD-13-13733-3).
Conflict-of-interest: The authors declare no conflicting interest.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tawfik Khoury, MD, Gastroeneterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem IL-91120, Israel. tawfikkhoury1@hotmail.com
Telephone: +972-2-6777816 Fax: +972-2-6431021
Received: November 11, 2014
Peer-review started: November 12, 2014
First decision: January 8, 2015
Revised: February 8, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: June 28, 2015
Processing time: 230 Days and 13.3 Hours
Core Tip

Core tip: Oral administration of the combination of OS and M1 soy derived extracts exerted an adjuvant effect in the gut-immune system, altering the distribution of regulatory T cells, and alleviating immune mediated liver injury, hyperlipidemia and insulin resistance. Oral administration of these extracts had an additive effect in alleviating concanavalin A hepatitis and ameliorated liver injury in the high fat diet model of non-alcoholic steatohepatitis, and in the methionine and choline reduced diet combined with the high fat diet model. The effects were associated with reduced serum tumor necrosis factor alpha and alteration of regulatory T cell distribution.