Editorial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2015; 21(24): 7349-7356
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7349
Effector and suppressor T cells in celiac disease
Giuseppe Mazzarella
Giuseppe Mazzarella, Immuno-Morphology Lab, Institute of Food Sciences, National Council Research, 83100 Avellino, Italy
Author contributions: Mazzarella G solely contributed to this paper
Conflict-of-interest: I have no competing interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Giuseppe Mazzarella, DSC, Immuno-Morphology Lab, Institute of Food Sciences, National Council Research, Via Roma 64, 83100 Avellino, Italy. gmazzarella@isa.cnr.it
Telephone: +39-825-299391 Fax: +39-825-299104
Received: January 28, 2015
Peer-review started: January 29, 2015
First decision: March 10, 2015
Revised: April 9, 2015
Accepted: May 2, 2015
Article in press: May 4, 2015
Published online: June 28, 2015
Processing time: 151 Days and 16.6 Hours
Core Tip

Core tip: Although it is evident that effector gliadin-specific Th1 cells play an important role in celiac disease (CD) pathogenesis, recent studies have implicated Th17 effector cells in the disease process. Contrasting evidence has been reported on the ability of gliadin-specific cells to produce IL-17A. In addition, regulatory T cells, formerly known as suppressor T cells, have been identified in intestinal biopsy specimens of patients with active CD. Nevertheless, despite the presence of an endogenous counter-regulatory mechanism in the intestinal mucosa of celiac patients, the inflammatory response is not suppressed. In this review, we provide an overview of the current knowledge of the contribution of both Th1 and Th17 effector T cells and Treg cells in controlling mucosal inflammation in CD.