Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2015; 21(23): 7208-7217
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7208
Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma
Ting-Ting Yu, Xi-Ming Xu, Yi Hu, Jun-Jian Deng, Wei Ge, Na-Na Han, Mei-Xia Zhang
Ting-Ting Yu, Xi-Ming Xu, Yi Hu, Jun-Jian Deng, Wei Ge, Na-Na Han, Mei-Xia Zhang, Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Yu TT and Xu XM contributed equally to this work; Yu TT, Xu XM, Hu Y, and Deng JJ designed research; Yu TT, Ge W, Han NN, and Zhang MX performed research; Yu TT, Han NN, and Zhang MX analyzed data; Yu TT and Xu XM wrote the paper.
Ethics approval: The study was approved by the Human Research Ethics Committee of Renmin Hospital of Wuhan University.
Conflict-of-interest: There are no conflicts of interest.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xi-Ming Xu, MD, PhD, Cancer Center, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuhan 430060, Hubei Province, China. vipdoctorxu@163.com
Telephone: +86-27-88042292 Fax: +86-27-88042292
Received: November 19, 2014
Peer-review started: November 19, 2014
First decision: December 11, 2014
Revised: December 26, 2014
Accepted: March 27, 2015
Article in press: March 27, 2015
Published online: June 21, 2015
Processing time: 212 Days and 18.5 Hours
Core Tip

Core tip: This manuscript examines the differential expression of long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma using gene ontology and pathway analyses, and constructing a long noncoding RNA-mRNA network to research the data. Furthermore, RNA immunoprecipitation revealed that the large intergenic noncoding RNA ULK4P2 physically combined with enhancer of zeste homolog 2 (EZH2). EZH2 plays an important role in many cancer types and is critical for cancer cell proliferation, survival, and metastasis, and drug resistance. The combination of ULK4P2 and EZH2 provides a novel avenue for further study of ULK4P2 in hepatitis B virus-related hepatocellular carcinoma.