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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2015; 21(22): 7008-7013
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.7008
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.7008
Efficacy of poly-unsaturated fatty acid therapy on patients with nonalcoholic steatohepatitis
Yun-Hua Li, Tong-Gang Liu, Li-Guo Zhang, Xian-Xian Liu, Department of Infectious Diseases, Binzhou Medical University Hospital, Binzhou 256603, Shandong Province, China
Lu-Hua Yang, Binzhou Medical University Hospital Outpatient Department, Binzhou Medical University Hospital, Binzhou 256603, Shandong Province, China
Kai-Hui Sha, Binzhou Medical University School of Nursing, Binzhou 256603, Shandong Province, China
Author contributions: Li YH, Yang LH, Sha KH, Zhang LG and Liu XX performed the study; Liu TG performed the statistic analyses; Yang LH wrote the article; and Li YH designed the study.
Ethics approval: The study was reviewed and approved by the Binzhou Medical University Hospital Institutional Review Board.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: The authors declare that they have no competing interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yun-Hua Li, MD, Department of Infectious Diseases, Binzhou Medical University Hospital, No. 661 Huanghe Erlu, Binzhou 256603, Shandong Province, China. yunhuali123@126.com
Telephone: +86-543-3257792
Received: December 28, 2014
Peer-review started: December 29, 2014
First decision: January 22, 2015
Revised: February 20, 2015
Accepted: April 9, 2015
Article in press: April 9, 2015
Published online: June 14, 2015
Peer-review started: December 29, 2014
First decision: January 22, 2015
Revised: February 20, 2015
Accepted: April 9, 2015
Article in press: April 9, 2015
Published online: June 14, 2015
Core Tip
Core tip: Epidemiologically, it has been reported that the prevalence of non-alcoholic fatty liver disease is increasing significantly and its associated morbidities, including non-alcoholic steatohepatitis (NASH) and hepatic failure, also impose great health and economic burdens on individuals and the whole of society. Preliminary data from our study showed that 6 mo poly-unsaturated fatty acid (PUFA) therapy improved NASH, as reflected by laboratory examination and histological evaluation. Future study is warranted to investigate whether long-term consumption of PUFA could completely reverse NASH and reduce the incidence of hepatic failure.