Huang J, Yang YS, Lu ZS, Wang SF, Yang J, Yuan J. Detection of superficial esophageal squamous cell neoplasia by chromoendoscopy-guided confocal laser endomicroscopy. World J Gastroenterol 2015; 21(22): 6974-6981 [PMID: 26078575 DOI: 10.3748/wjg.v21.i22.6974]
Corresponding Author of This Article
Yun-Sheng Yang, Professor, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, 100853 Beijing, China. huangjin034@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jin Huang, Department of Gastroenterology and Hepatology, Chinese PLA 153 Hospital, Zhengzhou 450000, Henan Province, China
Yun-Sheng Yang, Zhong-Sheng Lu, Shuang-Fang Wang, Jing Yang, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China
Jing Yuan, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Huang J and Yang YS designed the research; Huang J, Lu ZS, Wang SF and Yang J performed the research; Yuan J was responsible for the histological analysis; Huang J and Lu ZS analyzed the data; and Huang J wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yun-Sheng Yang, Professor, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, 100853 Beijing, China. huangjin034@163.com
Telephone: +86-10-55499005 Fax: +86-10-55499005
Received: September 20, 2014 Peer-review started: September 21, 2014 First decision: October 19, 2014 Revised: December 3, 2014 Accepted: January 21, 2015 Article in press: January 21, 2015 Published online: June 14, 2015 Processing time: 270 Days and 18.6 Hours
Core Tip
Core tip: The aim of the present study was to determine the diagnostic potential of confocal laser endomicroscopy (CLE) combined with Lugol’s iodine chromoendoscopy in detecting superficial esophageal squamous cell neoplasia (ESCN). Lugol’s chromoendoscopy-guided CLE was performed in 52 enrolled patients. In the same patients, chromoendoscopy-guided biopsy was performed by another endoscopist. A comparison of the detection rates between the CLE finding and biopsy was performed. The sensitivity, specificity, negative predictive value and positive predictive value of chromoendoscopy-guided CLE were 95.7%, 90%, 81.8% and 97.8%, respectively. There was a statistically significant difference in the detection of dysplasia between chromoendoscopy-guided CLE and biopsy. Lugol’s chromoendoscopy-guided CLE is a real-time, non-invasive endoscopic diagnostic technology; the accuracy of the detection of superficial ESCN is equivalent to or may be superior to biopsy histology.
