Editorial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2015; 21(22): 6817-6819
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6817
What are the effects of proton pump inhibitors on the small intestine?
Shunji Fujimori
Shunji Fujimori, Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo 113-8603, Japan
Author contributions: Fujimori S wrote the paper.
Conflict-of-interest: The author has no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shunji Fujimori, MD, PhD, Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. s-fujimori@nms.ac.jp
Telephone: +81-3-38222131 Fax: +81-3-56851793
Received: January 23, 2015
Peer-review started: January 24, 2015
First decision: March 10, 2015
Revised: March 24, 2015
Accepted: April 16, 2015
Article in press: April 17, 2015
Published online: June 14, 2015
Processing time: 146 Days and 7.9 Hours
Core Tip

Core tip: Proton-pump inhibitor (PPI) administration provokes dysbiosis of small intestinal bacterial flora, which exacerbates nonsteroidal anti-inflammatory drug-induced small intestinal injury. Dysbiosis is considered part of small intestinal bacterial overgrowth. Both PPI administration and gastrectomy increase the frequency of small intestinal bacterial overgrowth. Intestinal bacterial flora influence a number of systematic diseases. The influence of acid suppression therapy, especially PPIs, on small intestinal bacterial flora is worth noting.