Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2015; 21(21): 6582-6590
Published online Jun 7, 2015. doi: 10.3748/wjg.v21.i21.6582
Transplantation of insulin-producing cells to treat diabetic rats after 90% pancreatectomy
Ya-Bin Yu, Jian-Min Bian, Dian-Hua Gu
Ya-Bin Yu, Dian-Hua Gu, Department of Hepatobiliary Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, Jiangsu Province, China
Jian-Min Bian, Department of General Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
Author contributions: Gu DH designed the research; Yu YB performed the research and wrote the paper; Bian JM contributed new reagents/analytic tools; Yu YB and Bian JM analyzed the data.
Ethics approval: The study was reviewed and approved by the Huai’an First People’s Hospital Institutional Review Board.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Nanjing First Hospital Affiliated to Nanjing Medical University (IACUC protocol number: SYXK-2009-0015).
Conflict-of-interest: We declare that we have no conflict of interest.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at 531665908@qq.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dian-Hua Gu, MD, Department of Hepatobiliary Surgery, Huai’an First People’s Hospital, Nanjing Medical University, No. 140 Hanzhong Road, Huai’an 223300, Jiangsu Province, China. 531665908@qq.com
Telephone: +86-517-84907166 Fax: +86-517-84907166
Received: November 1, 2014
Peer-review started: November 3, 2014
First decision: November 26, 2014
Revised: December 18, 2015
Accepted: February 11, 2015
Article in press: February 11, 2015
Published online: June 7, 2015
Core Tip

Core tip: It is well known that islet transplantation can decrease the morbidity related to diabetes mellitus (DM) after total pancreatectomy (TP); however, islet shortage limits its application. To solve the islet shortage problem, we tried to induce mesenchymal stem cells isolated from human Wharton’s jelly to differentiate into insulin-producing cells (IPCs) in this study. To imitate the pathophysiological status of diabetic patients after TP, we used Sprague-Dawley rats after 90% pancreatectomy as a model of type 1 DM. We for the first time tested the possible curative effects of transplanting IPCs differentiated from umbilical cord mesenchymal stem cells into the model rats.