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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2015; 21(21): 6561-6571
Published online Jun 7, 2015. doi: 10.3748/wjg.v21.i21.6561
Published online Jun 7, 2015. doi: 10.3748/wjg.v21.i21.6561
Probiotic BIFICO cocktail ameliorates Helicobacter pylori induced gastritis
Hong-Jing Yu, Zhen Chang, Sha-Sha Wang, Lu Liu, Jun-Dong Zhang, Shanghai Sine Pharmaceutical Laboratories Co, Ltd, Shanghai 201206, China
Hong-Jing Yu, School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
Wei Liu, Hui Shen, Li-Juan He, Yuan-Ying Jiang, Guo-Tong Xu, Mao-Mao An, Jun-Dong Zhang, Department of Pharmacology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China
Yuan-Ying Jiang, New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Author contributions: Yu HJ and Liu W contributed equally to this work; An MM is co-corresponding author of this article; Liu W, Shen H, He LJ, Wang SS and Liu L performed the research; Chang Z, Jiang YY and Xu GT contributed essential reagents and tools; Yu HJ, An MM and Zhang JD designed the research study; Yu HJ and Liu W wrote and revised the paper.
Supported by National Natural Science Foundation of China, No. 81274164; Shanghai Manufacture-Education-Research-Medical Cooperative Project, No 12DZ1930505.
Ethics approval: The study was reviewed and approved by the Tongji University School of Medicine Institutional Review Board.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Tongji University School of Medicine (IACUC protocol number: TJLAC-014-012).
Conflict-of-interest: The authors declare that there is no conflict of interests regarding the publication of this article.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at Zhangjd534@163.com. Participants gave informed consent for data sharing. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jun-Dong Zhang, MD, Department of Pharmacology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. zhangjd534@163.com
Telephone: +86-21-65988562 Fax: +86-21-95988562
Received: November 30, 2014
Peer-review started: December 1, 2014
First decision: January 8, 2015
Revised: February 5, 2015
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: June 7, 2015
Processing time: 192 Days and 17.6 Hours
Peer-review started: December 1, 2014
First decision: January 8, 2015
Revised: February 5, 2015
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: June 7, 2015
Processing time: 192 Days and 17.6 Hours
Core Tip
Core tip: We investigated the effects of a traditional probiotic pharmaceutical cocktail in China, composed of the viable bacteria Enterococcus faecalis, Bifidobacterium longum and Lactobacillus acidophilus, on Helicobacter pylori (H. pylori)-induced gastritis in experimental mice and found that it could ameliorate H. pylori-induced gastritis by inhibiting the epithelial cell inflammatory response.