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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2015; 21(21): 6543-6549
Published online Jun 7, 2015. doi: 10.3748/wjg.v21.i21.6543
Published online Jun 7, 2015. doi: 10.3748/wjg.v21.i21.6543
Low G preconditioning reduces liver injury induced by high +Gz exposure in rats
Bin Shi, Zhi-Qiang Feng, Wen-Bing Li, Hong-Yi Zhang, Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital, Beijing 100142, China
Author contributions: Zhang HY and Shi B designed the research; Shi B and Li WB performed the research; Shi B and Feng ZQ analyzed the data; Shi B, Feng ZQ and Zhang HY wrote the paper.
Ethics approval: The study was reviewed and approved by the Chinese PLA Air Force General Hospital Institutional Review Board.
Conflict-of-interest: The authors declare there are no conflicts of interest to disclose.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hong-Yi Zhang, MD, PhD, Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital, No. 30 Fucheng Road, Beijing 100142, China. kjzygdwk@163.com
Telephone: +86-10-66928312 Fax: +86-10-66928312
Received: November 30, 2014
Peer-review started: November 30, 2014
First decision: January 8, 2015
Revised: February 4, 2015
Accepted: March 31, 2015
Article in press: March 31, 2015
Published online: June 7, 2015
Processing time: 192 Days and 13.9 Hours
Peer-review started: November 30, 2014
First decision: January 8, 2015
Revised: February 4, 2015
Accepted: March 31, 2015
Article in press: March 31, 2015
Published online: June 7, 2015
Processing time: 192 Days and 13.9 Hours
Core Tip
Core tip: We conducted this experimental study to explore an optimized strategy of reducing liver injury induced by high +Gz exposure, and to observe more specific indices of liver function, such as alanine transaminase, aspartate aminotransferase, malondialdehyde, superoxide dismutase, Na+-K+-ATPase and hepatic pathology. We found that low G preconditioning reduced oxidative stress and significantly improved Na+-K+-ATPase activity, inducing minimal liver injury.