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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2015; 21(20): 6341-6351
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6341
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6341
Proton pump inhibitors therapy vs H2 receptor antagonists therapy for upper gastrointestinal bleeding after endoscopy: A meta-analysis
Ying-Shi Zhang, Qing Li, Bo-Sai He, Ran Liu, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
Zuo-Jing Li, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
Author contributions: Zhang YS collected the data, performed the data analysis and wrote the paper; He BS and Liu R participated in the data collection; Li Q and Li ZJ designed the study and revised the paper; all authors read and approved the final manuscript.
Supported by National Natural Science Funds of China, No. 81102784/H2803; the key project in scientific research from ministry of education, No. 212032 and Liaoning Innovative Research Team in University, No. LT2013022.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qing Li, PhD, School of Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. lqyxm@hotmail.com
Telephone: +86-24-23984392 Fax: +86-24-23984392
Received: August 12, 2014
Peer-review started: August 13, 2014
First decision: September 15, 2014
Revised: September 23, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: May 28, 2015
Processing time: 290 Days and 18.8 Hours
Peer-review started: August 13, 2014
First decision: September 15, 2014
Revised: September 23, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: May 28, 2015
Processing time: 290 Days and 18.8 Hours
Core Tip
Core tip: Recently, the administration of proton pump inhibitors (PPI) or H2 receptor antagonists (H2RA) have been used commonly for upper gastrointestinal bleeding patients after successful endoscopic therapy; however, which drug class is more effective, remains controversial. In this meta-analysis, we concluded that in patients with upper gastrointestinal bleeding after successful endoscopic therapy, compared with H2RA, PPI may be a more effective therapy.