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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2015; 21(20): 6310-6316
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6310
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6310
Modified sequential therapy vs quadruple therapy as initial therapy in patients with Helicobacter infection
Xiao-Min Liao, Yi-Ying Huang, Bai-He Wu, Jin-Qi Wei, Department of Gastroenterology, the 5th Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China
Gao-Hui Nong, Department of Microbiology, Zhuhai Health School, Zhuhai 519000, Guangdong Province, China
Mei-Zu Chen, Department of Respiratory, the 5th Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China
Xue-Ping Huang, Yun-Yan Cong, Department of Oncology, the 5th Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China
Author contributions: Wei JQ and Cong YY designed the study; Cong YY and Liao XM performed the research; Liao XM, Nong GH, Chen MZ, Huang XP, Cong YY, Huang YY, Wu BH and Wei JQ contributed technical support; Wei JQ critically revised the manuscript; and Liao XM analyzed the data and wrote the paper.
Ethics approval: This study was reviewed and approved by the 5th Affiliated Hospital of Sun Yat-sen University Institutional Review Board.
Clinical trial registration: This study is registered at http://app1.sfda.gov.cn/datasearch/face3/base.jsp. The registration identification number is 2007S00884.
Informed consent: All study participants, or legal guardians where applicable, provided informed written consent prior to study enrollment.
Conflict-of-interest: Jin-Qi Wei has received fees for serving as an Associate Professor for the 5th Affiliated Hospital of Sun Yat-sen University. Jin-Qi Wei has received research funding from the 5th Affiliated Hospital of Sun Yat-sen University. Jin-Qi Wei is an employee of the 5th Affiliated Hospital of Sun Yat-sen University. Jin-Qi does not own shares in the 5th Affiliated Hospital of Sun Yat-sen University.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jin-Qi Wei, MD, Department of Gastroenterology, the 5th Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua Dong Road, Zhuhai 519000, Guangdong Province, China. liaoxm3@mail2.sysu.edu.cn
Telephone: +86-756-2528840
Received: December 31, 2014
Peer-review started: January 2, 2015
First decision: January 22, 2015
Revised: February 14, 2015
Accepted: March 18, 2015
Article in press: March 19, 2015
Published online: May 28, 2015
Peer-review started: January 2, 2015
First decision: January 22, 2015
Revised: February 14, 2015
Accepted: March 18, 2015
Article in press: March 19, 2015
Published online: May 28, 2015
Core Tip
Core tip: As the prevalence of antibiotic-resistant Helicobacter pylori (H. pylori) has increased in recent years, the eradication rate of H. pylori has simultaneously declined each year. The aim of this randomized controlled clinical trial was to better characterize the safety and efficacy of a modified sequential therapy regimen for the initial treatment of H. pylori and to compare this treatment regimen with a 10-d standard quadruple treatment regimen for the eradication of H. pylori.