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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 491-501
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.491
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.491
E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo
Wei-Yuan Wei, Lin-Hai Yan, Wen-Long Cao, Xiao-Shi Zhang, Ze-Xu Zhan, Han Yu, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xiao-Tong Wang, Lei Li, Department of Surgery, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Yu-Bo Xie, Department of Anaesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Xiao Q and Xie YB contributed equally to this work; Xiao Q and Xie YB designed the research; Wei WY, Yan LH, Wang XT and Li L performed the research; Cao WL, Zhang XS, Zhan ZX and Yu H provided the reagents; Wei WY analyzed the data and wrote the paper.
Supported by National Natural Science Foundation of China, No. 30860273 and No. 81060201; Natural Science Foundation of Guangxi, No. 2011GXNSFA018273 and No. 2013GXNSFAA019163; and the Key Health Science Project of Guangxi, No. Key1298003-2-6.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qiang Xiao, Professor, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Telephone: +86-771-5358325 Fax: +86-771-5358325
Received: March 18, 2014
Peer-review started: March 19, 2014
First decision: April 21, 2014
Revised: May 16, 2014
Accepted: July 16, 2014
Article in press: July 16, 2014
Published online: January 14, 2015
Processing time: 305 Days and 19.1 Hours
Peer-review started: March 19, 2014
First decision: April 21, 2014
Revised: May 16, 2014
Accepted: July 16, 2014
Article in press: July 16, 2014
Published online: January 14, 2015
Processing time: 305 Days and 19.1 Hours
Core Tip
Core tip: Transcription factor E2F-1 is the prototypical E2F and is often implicated in DNA synthesis and repair, cell proliferation, and apoptosis. Our preliminary study revealed that high expression of E2F-1 significantly suppressed gastric cancer (GC) cell line progression in vitro. However, the role of E2F-1 overexpression in GC in vivo remains unknown. Our results showed that overexpression of E2F-1 significantly inhibited tumor growth and promoted tumor cell apoptosis in vivo. Survivin, Bcl-2, cyclin D1, S-phase kinase-associated protein 2 and c-Myc were upregulated, and Bax was downregulated by E2F-1. E2F-1 inhibits growth of GC cells via regulating multiple signaling pathways.