Prospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2015; 21(17): 5336-5344
Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5336
Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer
Xu-Ren Sun, Zhe Sun, Zhi Zhu, Hai-Xia Guan, Chen-Yan Li, Jun-Yan Zhang, Yi-Ning Zhang, Huan Zhou, Hui-Jing Zhang, Hui-Mian Xu, Ming-Jun Sun
Xu-Ren Sun, Yi-Ning Zhang, Ming-Jun Sun, Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Zhe Sun, Zhi Zhu, Jun-Yan Zhang, Hui-Mian Xu, Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Hai-Xia Guan, Chen-Yan Li, Department of Endocrinology and Metabolism, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Huan Zhou, Hui-Jing Zhang, Ming-Jun Sun, Department of Gastrointestinal Endoscopy, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Sun MJ, Xu HM designed the research; Sun XR, Sun Z, Zhu Z, Zhang YN performed the research; Guan HX, Li CY contributed new reagents and analytic tools; Sun XR, Zhang HJ, Zhou H and Zhu Z analyzed the data; Sun XR, Zhang JY, Sun Z and Zhu Z wrote the paper.
Supported by Grants from the research projects in Liaoning Province Science and Technology Department, No. 2007225017, No. 2009225011-2 and No. 2011415052; Science and Technology projects in Shenyang City, No. F11-264-1-19.
Ethics approval: The study was reviewed and approved by the Research Ethics Committee of China Medical University.
Informed consent: All study participants or their legal guardians provided informed written consent prior to study enrollment.
Conflict-of-interest: All of the authors have no conflicts of interest.
Data sharing: No additional data are available
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ming-Jun Sun, MD, Department of Gastroenterology, First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China. smjmw@sina.com
Telephone: +86-24-83282175 Fax: +86-24-83282175
Received: October 14, 2014
Peer-review started: October 15, 2014
First decision: December 11, 2014
Revised: December 30, 2014
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: May 7, 2015
Processing time: 210 Days and 18.2 Hours
Core Tip

Core tip: This is the first reported study to evaluate the prognostic role of pyruvate dehydrogenase (PDH) expression in gastric cancer (GC). This study showed that reduced PDH expression was correlated with Lauren grade, lymph node metastasis, lymphatic invasion, histologic subtype and TNM stage in GC. We propose that increased PDH expression may contribute to a decrease in the proliferation and development of GC. In particular, PDH protein expression was found to positively correlate with survival in GC patients, and a high level of PDH expression was found to be associated with better overall survival in patients with resected GC. In conclusion, this study showed that PDH expression is an independent prognostic factor in gastric carcinomas.