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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2015; 21(16): 5039-5048
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5039
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5039
Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression
Seoung-Ae Lee, Hong Kim, Bum-Joon Kim, You-Sub Won, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea
Ki-Jeong Kim, Department of Microbiology, School of Medicine, Chung-Ang University, Seoul 110-799, South Korea
Won-Hyuk Choi, Department of Internal Medicine, Konkuk University, Seoul 110-799, South Korea
Author contributions: Kim BJ conceived this research and participated in its design and coordination; Lee SA, Kim KJ, Kim H and Choi WH performed the experiments and analyzed and interpreted the data; Choi WH and Won YS contributed the reagents, materials, and analysis tools; all authors approved the final manuscript; Lee SA, Kim KJ and Kim H equally contributed into this study.
Supported by Grants from National Research Foundation of Korea; grant funded by the Korean government (Ministry of Education, Science, and Technology), No. 2013-005810; and Foundation of Seoul National University Hospital (SNUH research fund), No. 0320140140.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bum-Joon Kim, Professor, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
Telephone: +82-2-7408316 Fax: +82-2-7430881
Received: September 23, 2014
Peer-review started: September 25, 2014
First decision: October 14, 2014
Revised: October 30, 2014
Accepted: January 16, 2015
Article in press: January 16, 2015
Published online: April 28, 2015
Processing time: 216 Days and 7 Hours
Peer-review started: September 25, 2014
First decision: October 14, 2014
Revised: October 30, 2014
Accepted: January 16, 2015
Article in press: January 16, 2015
Published online: April 28, 2015
Processing time: 216 Days and 7 Hours
Core Tip
Core tip: Our data indicate that the hepatitis B virus (HBV) genotype C preS1 deletion might significantly contribute to disease progression in chronic HBV subjects through an extended duration of Hepatitis B virus e antigen seropositive status and increased HBV replication. This study provides novel insight into the greater infectivity and virulence of genotype C compared with other genotypes. In addition, the fluorescence resonance energy transfer-based real-time polymerase chain reaction used to detect the preS1 deletion shows promise for the earlier prediction of the risk of liver disease progression in chronic HBV subjects.