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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2015; 21(15): 4715-4721
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4715
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4715
Antimicrobial prophylaxis in patients with colorectal lesions undergoing endoscopic resection
Qi-Sheng Zhang, Bing Han, Jian-Hua Xu, Peng Gao, Yu-Cui Shen, Digestive Endoscopy Center, Department of Gastroenterology and Hepatology, Branch of Shanghai First People’s Hospital, Jiaotong University, Shanghai 200081, China
Author contributions: Zhang QS and Han B designed the study and wrote the manuscript; Xu JH, Gao P and Shen YC performed the operation (ESD and EMR) and collected data.
Ethics approval: The study was reviewed and approved by the Branch of Shanghai First People’s Hospital Institutional Review Board.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: Authors declare no conflicts of interest or finance for this article to be disclosed.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qi-Sheng Zhang, MD, Digestive Endoscopy Center, Department of Gastroenterology and Hepatology, Branch of Shanghai First People’s Hospital, Jiaotong University, No. 1878 North Sichuan Road, Hongkou District, Shanghai 200081, China. zhangqish@hotmail.com
Telephone: +86-21-56663031 Fax: +86-21-56660851
Received: October 14, 2014
Peer-review started: October 16, 2014
First decision: November 14, 2014
Revised: November 25, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: April 21, 2015
Peer-review started: October 16, 2014
First decision: November 14, 2014
Revised: November 25, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: April 21, 2015
Core Tip
Core tip: We designed a controlled, randomized study to investigate the effect of prophylaxis with antibiotics on clinical adverse events in patients who underwent endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) procedures for colorectal lesions, and observed the value of surgical wound area as a risk factor. Clinical adverse events (abdominal pain, diarrhea, hematochezia and fever), leukocytosis and elevated levels of C-reactive protein are not uncommon after EMR or ESD procedures. Prophylactic antibiotics can reduce the incidence of clinical adverse events significantly. In addition, when the surgical wound area is larger than 10 mm × 10 mm, more clinical adverse events occur.