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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2015; 21(15): 4547-4554
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4547
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4547
Down-regulation of aquaporin3 expression by lipopolysaccharide via p38/c-Jun N-terminal kinase signalling pathway in HT-29 human colon epithelial cells
Feng-Xia Li, Li-Zhen Huang, Chuan Dong, Hong-Juan Wu, Shao-Min Shuang, School of Chemistry and Chemical Engineering, Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006, Shanxi Province, China
Feng-Xia Li, Jun-Ping Wang, Gastroenterology Department, Shanxi Provincial People’s Hospital, Taiyuan 030006, Shanxi Province, China
Author contributions: All authors contributed to this manuscript.
Supported by National Natural Foundations of China, No. 21175087; and the Task Projects of Shanxi Provincial Bureau of Health, No. 201201054.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Shao-Min Shuang, School of Chemistry and Chemical Engineering, Research Center of Environmental Science and Engineering, Shanxi University, No. 92 Wucheng Road, Taiyuan 030006, Shanxi Province, China. lifengxia33@163.com
Telephone: +86-351-4961994 Fax: +86-351-4961994
Received: September 20, 2014
Peer-review started: September 21, 2014
First decision: October 19, 2014
Revised: December 7, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: April 21, 2015
Peer-review started: September 21, 2014
First decision: October 19, 2014
Revised: December 7, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: April 21, 2015
Core Tip
Core tip: In this study we investigated the mRNA and protein expression levels of aquaporin 3 (AQP3) in HT-29 cells exposed to lipopolysaccharide. In addition, we examined the mechanism of regulation of AQP3 expression via the p38 and JNK signalling pathway in vitro.