Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2015; 21(14): 4373-4378
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4373
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4373
Ipilimumab associated colitis: An IpiColitis case series at MedStar Georgetown University Hospital
Pawan Rastogi, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Mohamed Sultan, Aline J Charabaty, Mark C Mattar, Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC 2007, United States
Michael B Atkins, Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC 20007, United States
Author contributions: Rastogi P reviewed cases, collected data, and wrote the manuscript and references; Sultan M formatted images and provided revisions to the manuscript; Mattar MC is the author guarantor, supervised the process, and made revisions to the manuscript; Charabaty AJ and Atkins MB provided invaluable support and revision to the manuscript; Procedures were conducted by physicians of the Department of Gastroenterology and Hepatology at MedStar Georgetown University Hospital.
Supported by MedStar Georgetown University Hospital, Washington, DC, United States.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mark C Mattar, MD, Department of Gastroenterology, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Main Building Second Floor, Washington, DC 20007, United States. mark.c.mattar@gunet.georgetown.edu
Telephone: +1-202-4441031 Fax: +1-877-3031462
Received: August 19, 2014
Peer-review started: August 20, 2014
First decision: September 27, 2014
Revised: October 22, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: April 14, 2015
Peer-review started: August 20, 2014
First decision: September 27, 2014
Revised: October 22, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: April 14, 2015
Core Tip
Core tip: The development of colitis in the setting of ipilimumab use has become of great concern. Treatment regimens, predictive factors, and prognostic indicators have yet to become standardized and elucidated. Here we present one of the largest case series of ipilimumab associated colitis at a single tertiary care institution, as well as our approach to evaluating and treating suspected cases.