Li YW, Chen ZG, Wang JC, Zhang ZM. Superparamagnetic iron oxide-enhanced magnetic resonance imaging for focal hepatic lesions: Systematic review and meta-analysis. World J Gastroenterol 2015; 21(14): 4334-4344 [PMID: 25892885 DOI: 10.3748/wjg.v21.i14.4334]
Corresponding Author of This Article
Zong-Ming Zhang, MD, PhD, Professor, Director, Department of General Surgery, Beijing Electric Power Hospital, Capital Medical University, No. 1 Taipingqiaoxili, Fengtai District, Beijing 100073, China. zhangzongming@mail.tsinghua.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
You-Wei Li, Department of Radiology, Beijing Chuiyangliu Hospital Affiliated to School of Medicine, Tsinghua University, Beijing 100022, China
Zheng-Guang Chen, Department of Radiology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
Ji-Chen Wang, Department of Radiology, Nanjing BenQ Hospital, Nanjing 210036, Jiangsu Province, China
Zong-Ming Zhang, Department of General Surgery, Beijing Electric Power Hospital, Capital Medical University, Beijing 100073, China
Author contributions: Zhang ZM designed the study; Li YW, Chen ZG and Wang JC searched and reviewed the literature; Wang JC provided analytic tools and analyzed the data; Li YW and Chen ZG wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zong-Ming Zhang, MD, PhD, Professor, Director, Department of General Surgery, Beijing Electric Power Hospital, Capital Medical University, No. 1 Taipingqiaoxili, Fengtai District, Beijing 100073, China. zhangzongming@mail.tsinghua.edu.cn
Telephone: +86-10-63503046 Fax: +86-10-63465865
Received: September 9, 2014 Peer-review started: September 10, 2014 First decision: October 14, 2014 Revised: October 25, 2014 Accepted: November 19, 2014 Article in press: November 19, 2014 Published online: April 14, 2015
Core Tip
Core tip: Relevant studies on the performance of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) in the detection and characterization of focal hepatic lesions were identified by searching PubMed, EMBASE, and the Cochrane Library databases for articles published between January 1988 and September 2014 via a systematic review and meta-analysis. The results show that SPIO-enhanced MRI is useful in differentiating between hepatocellular carcinomas (HCCs) and other focal hepatic lesions. Using hyperintensity on SPIO-enhanced T2*-weighted images as the criterion, the sensitivity for diagnosing advanced HCC was 98%. SPIO-enhanced MRI is a valuable tool for the detection and characterization of focal lesions in cirrhotic liver.
