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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2015; 21(13): 3850-3859
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3850
Adjuvant therapy for gastric cancer: What have we learned since INT0116?
Alexandre A Jácome, Ajith K Sankarankutty, José Sebastião dos Santos
Alexandre A Jácome, Department of Medical Oncology, Hospital Mater Dei, Belo Horizonte 30190-131, Minas Gerais, Brazil
Ajith K Sankarankutty, José Sebastião dos Santos, Department of Surgery and Anatomy, University of São Paulo at Ribeirão Preto, School of Medicine, Ribeirão Preto14049-900, São Paulo, Brazil
Author contributions: Jácome AA, Sankarankutty AK and dos Santos JS contributed equally to this work; Jácome AA, Sankarankutty AK and dos Santos JS performed the literature review and wrote and reviewed the paper.
Supported by Fundação Waldemar Barnsley Pessoa, Brazil.
Conflict-of-interest: The authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alexandre A Jácome, MD, PhD, Department of Medical Oncology, Hospital Mater Dei, Av. Barbacena, 1057, Belo Horizonte 30190-131, Minas Gerais, Brazil. jacome@usp.br
Telephone: +55-31-33399022 Fax: +55-31-33399022
Received: December 9, 2014
Peer-review started: December 9, 2014
First decision: January 8, 2015
Revised: January 27, 2015
Accepted: February 11, 2015
Article in press: February 11, 2015
Published online: April 7, 2015
Processing time: 119 Days and 13.1 Hours
Core Tip

Core tip: Adjuvant therapy of gastric cancer significantly improves overall survival. The most accepted adjuvant therapy in the Western world is chemoradiotherapy according to the pivotal INT0116 study. However, in the time following its publication, other adjuvant treatment modalities have been discussed, and significant improvements have been obtained in our understanding of the multimodal approach of gastric cancer. The present review reports on the major advances obtained in the last decades in the adjuvant treatment of gastric cancer as well as the perspectives of treatment based on recent knowledge of the molecular biology of the disease.