Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2015; 21(10): 2949-2958
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2949
Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R
Yu Gong, Jun Ren, Kun Liu, Li-Ming Tang
Yu Gong, Jun Ren, Kun Liu, Li-Ming Tang, Department of Gastrointestinal Surgery, Nanjing Medical University Affiliated Changzhou No. 2 People’s Hospital, Changzhou 213000, Jiangsu Province, China
Author contributions: Gong Y and Ren J performed the majority of the experiments and collected the clinical data; Liu K provided vital reagents and analytical tools and was also involved in revising the manuscript; Tang LM designed the study and wrote the paper.
Supported by Nanjing Medical University institutional grant, No. 11ZLKF06 (to SYC and LMT); and the Changzhou basic research program of science and technology, No. CJ20122014.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Li-Ming Tang, MD, PhD, Department of Gastrointestinal Surgery, Nanjing Medical University Affiliated Changzhou No. 2 People’s Hospital, No. 188 Gehu Road, Changzhou 213000, Jiangsu Province, China. drtanglm@njmu.edu.cn
Telephone: +86-519-81087722 Fax: +86-519-81087711
Received: July 17, 2014
Peer-review started: July 17, 2014
First decision: August 6, 2014
Revised: August 29, 2014
Accepted: October 21, 2014
Article in press: October 21, 2014
Published online: March 14, 2015
Processing time: 242 Days and 2.2 Hours
Core Tip

Core tip: miRNA (miR)-133a is a tumor suppressor in several cancers. It was recently shown that miR-133a inhibits proliferation, migration and invasion in gastric cancer (GC) by targeting transcription factor Sp1. Here, we further investigated the biological role of miR-133a in apoptosis and xenograft tumorigenesis, and its relationship with clinicopathological parameters. miR-133a downregulation was associated with degree of differentiation, local invasion and TNM stage, whereas forced miR-133a expression inhibited cell proliferation, migration and invasion, and xenograft tumorigenesis, and induced apoptosis. Furthermore, insulin-like growth factor 1 receptor was found to be another target gene of miR-133a in GC.