Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2015; 21(10): 2912-2917
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2912
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2912
Inhibitory effect of TongXie-YaoFang formula on colonic contraction in rats
Cheng Yang, Sheng-Sheng Zhang, Zheng-Fang Wang, Lu-Qing Zhao, Digestive Disease Diagnosis and Treatment Center, Beijing Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China
Xiao-Ling Li, Basic Medicine College, Beijing University of Chinese Medicine, Beijing 100010, China
Author contributions: Yang C contributed to the study design and data interpretation, and wrote the manuscript; Zhang SS contributed to the study design; Li XL performed the majority of experiments and data analysis; Wang ZF and Zhao LQ contributed to the majority of quality control for the herbs of the formula.
Supported by National Nature Science Foundation of China, No. 81473644; the Clinical Medicine Development Project of Beijing Municipal Administration of Hospitals, No. ZY201411; the Project of Health Technical Personnel of the Beijing Health System, No. 2011-2-13.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sheng-Sheng Zhang, PhD, Professor, Digestive Disease Diagnosis and Treatment Center, Beijing Chinese Medicine Hospital, Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China. zhss2000@163.com
Telephone: +86-10-52176634 Fax: +86-10-52176634
Received: July 31, 2014
Peer-review started: August 2, 2014
First decision: August 27, 2014
Revised: September 20, 2014
Accepted: November 30, 2014
Article in press: December 1, 2014
Published online: March 14, 2015
Processing time: 227 Days and 20.2 Hours
Peer-review started: August 2, 2014
First decision: August 27, 2014
Revised: September 20, 2014
Accepted: November 30, 2014
Article in press: December 1, 2014
Published online: March 14, 2015
Processing time: 227 Days and 20.2 Hours
Core Tip
Core tip: Diarrhea-predominant irritable bowel syndrome (D-IBS) is a chronic gastrointestinal disease that seriously affects quality of life. Colon dysmotility is recognized as one of the pathophysiological factors. TongXie-YaoFang formula can effectively relieve diarrhea and lower visceral hypersensitivity in D-IBS rats, mainly via inhibiting the amplitude and frequency of colonic longitudinal smooth muscle contraction. Its action of mechanism may be related to the activation of specific potassium channels, inhibition of extracellular calcium internal flow, and reduction of intracellular free Ca2+ concentration.