Kuehn F, Klar E, Bliemeister A, Linnebacher M. Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease. World J Gastroenterol 2015; 21(1): 221-228 [PMID: 25574094 DOI: 10.3748/wjg.v21.i1.221]
Corresponding Author of This Article
Michael Linnebacher, PhD, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, Schillingallee 35, 18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 7, 2015; 21(1): 221-228 Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.221
Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease
Florian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher
Florian Kuehn, Ernst Klar, Anja Bliemeister, Michael Linnebacher, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, 18057 Rostock, Germany
Author contributions: Kuehn F acquired, analyzed and interpreted data, performed statistics and drafted the manuscript; Klar E delivered material support and critically revised the manuscript for important intellectual content; Bliemeister A acquired data and performed statistics; Linnebacher M designed and supervised the study, drafted and critically revised the manuscript.
Supported by University of Rostock (FORUN program)
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michael Linnebacher, PhD, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, Schillingallee 35, 18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de
Telephone: +49-381-4946043 Fax: +49-381-4946002
Received: May 14, 2014 Peer-review started: May 14, 2014 First decision: June 27, 2014 Revised: July 20, 2014 Accepted: August 13, 2014 Article in press: August 28, 2014 Published online: January 7, 2015 Processing time: 237 Days and 20.8 Hours
Core Tip
Core tip: Oxidative stress resulting from chronic inflammation is likely to relax the mismatch repair (MMR) system and to cause DNA damage. On the other hand thiopurine treatment positively selects for cell variants with defective MMR system. inflammatory bowel disease (IBD) patients are often exposed to both factors, hypothetically resulting in an increased number of frameshift mutations. This study shows an increased immune response towards microsatellite-instability-induced frameshift-peptides (FSPs) in patients with IBD. It is the first report which provides functional evidence of FSP expression under non- but possible pre-neoplastic conditions. These findings have potential implications for screening, diagnosis as well as clinical management of IBD patients.
