Ueda T, Hokari R, Higashiyama M, Yasutake Y, Maruta K, Kurihara C, Tomita K, Komoto S, Okada Y, Watanabe C, Usui S, Nagao S, Miura S. Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine. World J Gastroenterol 2015; 21(1): 177-186 [PMID: 25574090 DOI: 10.3748/wjg.v21.i1.177]
Corresponding Author of This Article
Ryota Hokari, MD, Professor, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. ryota@ndmc.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Toshihide Ueda, Ryota Hokari, Masaaki Higashiyama, Yuichi Yasutake, Koji Maruta, Chie Kurihara, Kengo Tomita, Shunsuke Komoto, Yoshikiyo Okada, Chikako Watanabe, Shingo Usui, Shigeaki Nagao, Soichiro Miura, Department of Internal Medicine, National Defense Medical College, Saitama 359-8513, Japan
Author contributions: All authors contributed to the manuscript.
Supported by National Defense Medical College, by Intractable Diseases, the Health and Labour Sciences Research Grants from Ministry of Health, Labour and Welfare and by Research for the similarity and difference in epidemiology, pathophysiology, diagnosis and treatment of rare intestinal refractory diseases and by a grant from the Smoking Research Foundation
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ryota Hokari, MD, Professor, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. ryota@ndmc.ac.jp
Telephone: +81-4-29951609 Fax: +81-4-29955201
Received: March 7, 2014 Peer-review started: March 7, 2014 First decision: April 2, 2014 Revised: May 11, 2014 Accepted: September 18, 2014 Article in press: September 19, 2014 Published online: January 7, 2015 Processing time: 306 Days and 2.2 Hours
Core Tip
Core tip: Non-steroidal anti-inflammatory drugs (NSAIDs) frequently induce mucosal damage in the gastrointestinal tract. The recently developed techniques of capsule enteroscopy and double balloon enteroscopy have shown that NSAIDs cause ulcers in the small intestine (68%) more frequently than previously thought. Although proton pump inhibitors are key drugs for NSAIDs-induced gastropathy, proton pump inhibitors have no effect on NSAIDs-induced intestinal lesions and no drugs are currently available for the prevention and treatment of NSAIDs-induced intestinal lesions. In the present study, we showed the beneficial effect of an omega-6 PUFA-rich diet in NSAID-induced mucosal damage in the murine small intestine. This is a completely novel finding and is important not only in the clinical field, but also in preventive medicine.
