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World J Gastroenterol. Mar 7, 2014; 20(9): 2403-2411
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2403
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2403
Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure
Su-Jun Zheng, Shuang Liu, Mei Liu, Jun-Feng Li, Feng Ren, Yu Chen, Zhong-Ping Duan, Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Malcolm A McCrae, The Pirbright Institute, Pirbright GU24 ONF, United Kingdom
Jun-Feng Li, Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Yuan-Ping Han, The Center for Growth, Metabolism and Aging Research, College of Life Sciences, Sichuan University, Chengdu 610065, Sichuan Province, China
Chun-Hui Xu, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
Author contributions: Zheng SJ and Liu S contributed equally to this work; Zheng SJ designed the study and performed the majority of experiments; Liu S designed the study and wrote the manuscript; Liu M and Ren F collected all the human materials; McCrae MA and Han YP revised the manuscript; Li JF and Xu CH analyzed the data; Chen Y and Duan ZP designed the study.
Supported by National Science and Technology Key Project of China on “Major Infectious Diseases”, No. 2012ZX10002004-006, No. 2012ZX10004904-003-001, No. 2013ZX10002002-006-001; Beijing Municipal Science and Technology Commission, No. Z131107002213019, No. Z131100004613030; High Technical Personnel Training Program in Beijing Health System, No. 2011-3-083, No. 2013-3-071; Special Scientific Research Fund for Beijing Health Development, No. 2011-2018-04; National Natural Science Foundation of China, No.30800979, No. 30800517
Correspondence to: Yu Chen, PhD, MD, Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, No. 8, Xitou Tiao Road, Youwai Street, Beijing 100069, China. chybeyond@163.com
Telephone: +86-10-63291007 Fax: +86-10-63295285
Received: September 21, 2013
Revised: December 31, 2013
Accepted: January 19, 2014
Published online: March 7, 2014
Processing time: 168 Days and 3.5 Hours
Revised: December 31, 2013
Accepted: January 19, 2014
Published online: March 7, 2014
Processing time: 168 Days and 3.5 Hours
Core Tip
Core tip: Massive hepatic cell death is a key characteristic of liver failure. Enzyme-linked immunosorbent assay was used to measure M65 and M30 in a chronic hepatitis B (CHB) infection cohort which included healthy controls, CHB and acute-on-chronic liver failure (ACLF) patients. Elevated M65 and M30 differentiated CHB or ACLF patients from healthy controls and gradually increased with disease severity. M30/M65 was significantly increased in ACLF patients with spontaneous recovery (P = 0.032), and the AUC of this ratio at the 3-mo survival period was 0.661 (sensitivity: 52.9%) with a high specificity (92.6%) compared with the Model for End-Stage Liver Disease and Child-Pugh scores.