Guo JW, Zhang XT, Chen XS, Zhang XC, Zheng GJ, Zhang BP, Cai YF. Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: A case report. World J Gastroenterol 2014; 20(8): 2120-2126 [PMID: 24587686 DOI: 10.3748/wjg.v20.i8.2120]
Corresponding Author of This Article
Ye-Feng Cai, Professsor, Brain Centre, Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. jianwen_guo@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jian-Wen Guo, Xiao-Sheng Chen, Xin-Chun Zhang, Guang-Juan Zheng, Bei-Ping Zhang, Ye-Feng Cai, Brain Centre, Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Xiao-Tian Zhang, Department of GI Oncology, Peking University Cancer Hospital and School of Oncology, Beijing 100142, China
Author contributions: Guo JW, Zhang XT and Cai YF reviewed the literature, collected the information, provided care to the patient, and wrote the manuscript; Chen XS, Zhang XC, Zheng GJ and Zhang BP were involved in the respective stage of the diagnosis, care, and management of the patient, provided constructive criticisms, revised and approved the final draft; and Zhang XT supervised the entire process from drafting the paper to submitting the manuscript to the journal.
Supported by Research Fund for the Doctoral Program of Higher Education of China, No.20104425120009
Correspondence to: Ye-Feng Cai, Professsor, Brain Centre, Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. jianwen_guo@qq.com
Telephone: +86-20-81887233 Fax: +86-20-81867705
Received: August 28, 2013 Revised: December 9, 2013 Accepted: January 8, 2014 Published online: February 28, 2014
Core Tip
Core tip: Here we report on a patient, initially and alone, presented with neurological symptoms and signs without any clues indicating gastric cancer. Evidence shows that the tumor directly spread solely to the brain without involvement of any other organs or tissues. How do we make an accurate and rapid diagnosis? Cerebral spinal fluid cytological studies play a key role in diagnosis, finding malignant cells that originate from epithelial cells. A gastroscopic examination was performed, revealing a tumor in the gastric antrum which was classified as Bormann type I in macroscopic appearance, a rare type in Bormann classification, however, with poor differentiation in pathology. This patient survived for 4 mo without treatment. It is unclear whether this particular form of metastasis affects clinical outcomes.
