Lim SM, Lim JY, Cho JY. Targeted therapy in gastric cancer: Personalizing cancer treatment based on patient genome. World J Gastroenterol 2014; 20(8): 2042-2050 [PMID: 24587678 DOI: 10.3748/wjg.v20.i8.2042]
Corresponding Author of This Article
Dr. Jae Yong Cho, MD, PhD, Department of Medical Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, South Korea. chojy@yuhs.ac
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
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World J Gastroenterol. Feb 28, 2014; 20(8): 2042-2050 Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.2042
Targeted therapy in gastric cancer: Personalizing cancer treatment based on patient genome
Sun Min Lim, Jae Yun Lim, Jae Yong Cho
Sun Min Lim, Division of Medical Oncology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, South Korea
Jae Yun Lim, Jae Yong Cho, Department of Medical Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, South Korea
Author contributions: Lim JY and Cho JY designed the study; Lim JY performed the research and data analysis; Lim SM and Lim JY contributed new reagents and analytical tools; Lim SM, Lim JY and Cho JY wrote the manuscript.
Correspondence to: Dr. Jae Yong Cho, MD, PhD, Department of Medical Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, South Korea. chojy@yuhs.ac
Telephone: +82-2-20194363 Fax: +82-2-34633882
Received: September 24, 2013 Revised: November 15, 2013 Accepted: December 12, 2013 Published online: February 28, 2014 Processing time: 154 Days and 15.6 Hours
Core Tip
Core tip: Understanding the molecular mechanisms governing carcinogenesis, progression and prognosis of gastric cancer is a prerequisite for development of effective management strategies. Analysis of genomic and proteomic expression profiles of oncogenic signaling pathways have revealed different molecular subtypes of gastric cancer. Development of personalized cancer therapy regimens will specifically target aberrations that drive tumor growth and survival. Therefore, identifying and administering the appropriate drug based on genetic profiling will improve clinical outcomes and decrease toxicity. We anticipate that identification of novel cancer targets will further aid in understanding of cancer heterogeneity and in refinement of personalized therapeutic strategies.
