Bhardwaj EK, Else KJ, Rogan MT, Warhurst G. Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice. World J Gastroenterol 2014; 20(7): 1797-1806 [PMID: 24587657 DOI: 10.3748/wjg.v20.i7.1797]
Corresponding Author of This Article
Geoffrey Warhurst, PhD, Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Clinical Sciences Building, Salford M68HD, United Kingdom. geoffrey.warhurst@manchester.ac.uk
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
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World J Gastroenterol. Feb 21, 2014; 20(7): 1797-1806 Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1797
Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice
Ekta K Bhardwaj, Kathryn J Else, Michael T Rogan, Geoffrey Warhurst
Ekta K Bhardwaj, Michael T Rogan, Geoffrey Warhurst, School of Environment and Life Sciences, University of Salford, Salford M68HD, United Kingdom
Kathryn J Else, Faculty of Life Sciences, University of Manchester, Manchester M139PT, United Kingdom
Geoffrey Warhurst, Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Salford M68HD, United Kingdom
Author contributions: Bhardwaj EK contributed to the study design, data acquisition and analysis and to data interpretation and manuscript drafting and revision; Else KJ, Rogan MT and Warhurst G contributed to study design, data interpretation and manuscript drafting and revision; all authors gave final approval to the final version of the article.
Correspondence to: Geoffrey Warhurst, PhD, Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Clinical Sciences Building, Salford M68HD, United Kingdom. geoffrey.warhurst@manchester.ac.uk
Telephone: +44-161-2064403
Received: August 27, 2013 Revised: October 17, 2013 Accepted: November 18, 2013 Published online: February 21, 2014 Processing time: 196 Days and 11.8 Hours
Core Tip
Core tip: This study investigates the interaction between the helminth parasite Trichuris muris (T. muris) and Mdr1a-/- mice, a genetic model of inflammatory bowel disease linked to deficiency of a key transporter protein in the gut barrier. The main findings are that (1) Mdr1a mice exhibit dramatically increased susceptibility to worm infection compared to congenic controls and (2) challenge with T. muris induces severe pathological changes consistent with a marked exacerbation of colitis in this model with preliminary evidence pointing to worm persistence as a driver of this effect. These findings will be of interest in the emerging field of helminth therapy in inflammatory bowel disease (IBD) providing further evidence of the complexity of worm interaction with an IBD-susceptible host.
