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World J Gastroenterol. Feb 14, 2014; 20(6): 1424-1437
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1424
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1424
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs
Aline Cristina Targa Cadamuro, Ana Flávia Teixeira Rossi, Nathália Maciel Maniezzo, Ana Elizabete Silva, Department of Biology, UNESP-São Paulo State University, Campus São José do Rio Preto, 15054-000 São José do Rio Preto, SP, Brazil
Author contributions: All authors contributed equally to wrote this review.
Correspondence to: Ana Elizabete Silva, PhD, Department of Biology, UNESP-São Paulo State University, Campus São José do Rio Preto, Rua Cristóvão Colombo, 2265, 15054-000 São José do Rio Preto, SP, Brazil. anabete@ibilce.unesp.br
Telephone: +55-17-32212384 Fax: +55-17-32212390
Received: October 11, 2013
Revised: December 18, 2013
Accepted: January 3, 2014
Published online: February 14, 2014
Revised: December 18, 2013
Accepted: January 3, 2014
Published online: February 14, 2014
Core Tip
Core tip: In this review, we focused some aspects of Helicobacter pylori (H. pylori) infection as bacterial virulence factor and mainly on modulation of host immune response and changes in the pattern of gene expression in H. pylori-infected gastric mucosa, with activation of gene transcription involved in inflammatory and immunological response, cell proliferation and apoptosis. We also highlighted the role of bacteria eradication for the normalization of gene expression levels. In addition, we addressed the recent involvement of different microRNAs in normal gastric mucosa, precancerous lesions, gastric cancer, and inflammatory processes induced by bacteria, showing deregulated expression.