Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats

doi:10.3748/wjg.v20.i48.18330

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2014; 20(48): 18330-18337
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18330

Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats

Duangporn Werawatganon, Narisorn Rakananurak, Sasipim Sallapant, Piyapan Prueksapanich, Kanjana Somanawat, Naruemon Klaikeaw, Rungsun Rerknimitr

Duangporn Werawatganon, Kanjana Somanawat, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Narisorn Rakananurak, Sasipim Sallapant, Piyapan Prueksapanich, Rungsun Rerknimitr, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Naruemon Klaikeaw, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

Author contributions: Werawatganon D designed the study, performed the experiments, analyzed the data and edited the manuscript; Rakananurak N, Sallapant S, Prueksapanich P, Rerknimitr R and Somanawat K performed the experiments, collected the data and wrote the manuscript; and Klaikeaw N co-ordinated in the pathological examination.

Supported by 90^th Anniversary Fund of Chulalongkorn University (Ratchada phiseksomphot Endowment Fund) and The Grant of Ratchadaphiseksomphot, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Correspondence to: Duangporn Werawatganon, MD, Associate Professor, Department of Physiology, Faculty of Medicine, Chulalongkorn University, 254 Phyathai Road, Patumwan, Bangkok 10330, Thailand. dr.duangporn@gmail.com

Telephone: +66-2-2564267 Fax: +66-2-2564267

Received: May 4, 2014
Revised: August 6, 2014
Accepted: September 5, 2014
Published online: December 28, 2014

Core Tip

Core tip: Nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastric damage is the major side effect of this kind of medication. Although the underlying pathogenesis of NSAIDs-induced gastric damage is unclear, neutrophils are believed to play an important role in the development of gastric inflammation and injury following NSAIDs administration. Aloe vera (Aloe barbadensis Mill) possesses several biological activities, including an anti-inflammatory and ulcer healing effects. The authors postulated that Aloe vera, acting through inflammatory inhibition, could reduce the inflammatory cytokine, neutrophil chemoattractant, and oxidative stress thus resulting in attenuation of gastric injury in indomethacin-induced gastropathy in rats.