Zuo L, Yuan KT, Yu L, Meng QH, Chung PCK, Yang DH. Bifidobacterium infantis attenuates colitis by regulating T cell subset responses. World J Gastroenterol 2014; 20(48): 18316-18329 [PMID: 25561798 DOI: 10.3748/wjg.v20.i48.18316]
Corresponding Author of This Article
Ding-Hua Yang, MD, PhD, Professor, Department of Hepatobiliary Surgery, Nan Fang Hospital, Southern Medical University, 1838 North Guangzhou Dadao, Guangzhou 510515, Guangdong Province, China. dhyang5810@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
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World J Gastroenterol. Dec 28, 2014; 20(48): 18316-18329 Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18316
Bifidobacterium infantis attenuates colitis by regulating T cell subset responses
Li Zuo, Kai-Tao Yuan, Li Yu, Qing-Hong Meng, Peter Chee-Keung Chung, Ding-Hua Yang
Li Zuo, Qing-Hong Meng, Peter Chee-Keung Chung, Department of Immunology, Guiyang Medical College, Guiyang 550004, Guizhou Province, China
Kai-Tao Yuan, Department of Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Li Yu, Department of Paediatrics, Guangzhou First Municipal People’s Hospital, Guangzhou 510180, Guangdong Province, China
Ding-Hua Yang, Department of Hepatobiliary Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Zuo L and Yuan KT contributed equally to this work; Zuo L and Yang DH designed the research; Zuo L, Yuan KT, Yu L and Meng QH performed the research; Chung PCK and Yang DH contributed to the new reagents and analytic tools; Zuo L, Yuan KT and Yang DH analyzed the data; Zuo L and Yuan KT wrote the paper.
Supported by Guangzhou Baoxing Biotechnology Company
Correspondence to: Ding-Hua Yang, MD, PhD, Professor, Department of Hepatobiliary Surgery, Nan Fang Hospital, Southern Medical University, 1838 North Guangzhou Dadao, Guangzhou 510515, Guangdong Province, China. dhyang5810@yahoo.com
Telephone: +86-20-61641706 Fax: +86-20-61641706
Received: October 30, 2013 Revised: May 24, 2014 Accepted: July 22, 2014 Published online: December 28, 2014
Core Tip
Core tip: Inflammatory bowel disease is a common autoimmune disorder characterized by chronic inflammation of the gastrointestinal tract. Abnormal immune cell responses contribute to the pathogenesis of the colitis. Probiotics are found to regulate the intestinal immune system and play a beneficial role in treating colitis. In our study, we showed that Bifidobacterium infantis (B. infantis) reduced the intestinal inflammation in TNBS-induced colitis mice though decreasing the Th1 and Th17 responses and promoting the Foxp3+ Treg response in mesenteric lymph nodes. This mechanism underlying the regulatory effect of B. infantis on the immune system may have significant clinical implications in treating inflammatory bowel disease and preventing colorectal cancer.
